|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that ERCC5/XPG rs2094258 and rs873601 and ERCC2/XPD rs238406 SNPs were independently associated with poorer DFS and OS of ESCC patients [ERCC5/XPG rs2094258: CT+TT vs. CC: adjusted hazards ratio (adjHR) = 1.68 and P = 0.012 for DFS; adjHR = 1.99 and P = 0.0001 for OS; ERCC5/XPG rs873601: GA+GG vs. AA: adjHR = 1.59 and P = 0.024 for DFS; adjHR = 1.91 and P = 0.0005 for OS; ERCC2/XPD rs238406: TT vs. GG+GT: adjHR = 1.43 and P = 0.020 for DFS; adjHR = 1.52 and P = 0.008 for OS].
|
27246611 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The XPD Asp312Asn (rs1799793) was found to be associated with the risk of developing second primary ESCC (P=0.015).
|
26054330 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Potentially functional polymorphisms in the ERCC2 gene and risk of esophageal squamous cell carcinoma in Chinese populations.
|
25209371 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggested that genetic variations in the ERCC2 gene were associated with risk of ESCC, and there was a significant interaction between gene polymorphisms and family history of cancer in the etiology of ESCC.
|
24390613 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis suggested that the ERCC2 Asp312Asn polymorphism might be associated with increased risk of esophageal adenocarcinoma and a protective factor for esophageal squamous cell carcinoma.
|
24234258 |
2014 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of XPD genetic polymorphisms of esophageal squamous cell carcinoma in a population of Yili Prefecture, in Xinjiang, China.
|
21553048 |
2012 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic variation in COMT Val158Met and XPD Lys751Gln may be important for ESCC susceptibility.
|
20979431 |
2011 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Increased risk of ESCC was suggested in ALDH2 for frequency of presence C allele of SNP [Rs886205: 1.626 (1.158-2.284)], XPD for C allele [Rs50872: 1.482 (1.058-2.074)], and MGMT for A allele [Rs11016897: 1.666 (1.245-2.228)].
|
20128036 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression levels of four genes (hMSH2, XRCC1, XPD, MGMT) present in PBMC were significantly correlated with increased risk for ESCC, in which there was reduced expression of MGMT, suggesting an important etiology role for MGMT expression in the initiation of ESCC in Huaian of China.
|
17479411 |
2007 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Upon analysis of gene-gene interaction, a relationship was observed, although statistically nonsignificant, between combined genotypes of XRCC1 (Arg/Gln-Gln/Gln)-ERCC2 Gln/Gln (OR = 0.33, 95% CI = 0.09-1.16) and XRCC1 (Gln/Gln)-ERCC2 (Lys/Gln) (OR = 0.36, 95% CI = 0.11-1.17) and reduced risk of ESQCC in the North Indian population.
|
17556064 |
2007 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Excess risks for esophageal SCC were also noted for XPD 751Gln variant genotypes.
|
16571649 |
2006 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that XPD 751 Gln/Gln genotype may be contributing factors in the risk of ESCC and may modify risk attributable to environmental exposures.
|
15381366 |
2004 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neither Asp312Asn nor Lys751Gln polymorphisms in the XPD gene influenced risk of ESCC in our study.
|
12124811 |
2002 |