Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 GeneticVariation disease BEFREE In a hospital-based case-control study of 1,004 PCa cases and 1,055 cancer-free controls, we genotyped eight potentially functional single nucleotide polymorphisms (SNPs) of NER genes (i.e., XPC, rs2228001 T>G and rs1870134 G>C; XPD, rs13181 T>G and rs238406 G>T; XPG, rs1047768 T>C, rs751402 C>T, and rs17655 G>C; and XPF, rs2276464 G>C) and assessed their associations with risk of PCa by using logistic regression analysis. 27974699 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 GeneticVariation disease BEFREE Impact of two common xeroderma pigmentosum group D (XPD) gene polymorphisms on risk of prostate cancer. 23028604 2013
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 GeneticVariation disease BEFREE Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population. 22116596 2012
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 GeneticVariation disease BEFREE We examined the association between PC risk with nonsynonymous SNPs (nsSNPs) in 5 genes involved in 3 DNA-repair pathways: (1) base excision repair (BER): hOGG1 C1245G (Ser326Cys) and XRCC1 G28152A (Arg399Gln); (2) nucleotide excision repair (NER): XPD G23591A (Asp312Asn); (3) homologous recombination repair: RAD51 G135C (in 5' untranslated region) and XRCC3 C18067T (Thr241Met). 19914098 2012
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 GeneticVariation disease BEFREE Genetic variation in other tumour suppressors (e.g. p53 and XPD) is reported to modify cancer progression/outcome, and single nucleotide polymorphisms (SNPs) within the WWOX gene are reported to associate with prostate cancer risk. 20074932 2010
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 Biomarker disease BEFREE Two of the common single-nucleotide polymorphisms X-ray repair cross-complementing group 1 (XRCC1) and Xeroderma pigmentosum group D (XPD) genes in PCa, which is one of the most common neoplasias in men all over the world, have been studied. 20070155 2010
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 GeneticVariation disease BEFREE In this study, we identified SNPs in LIG4, ERCC2, and CYP2D6 genes as putative markers to predict individuals at risk for complications arising from radiation therapy in prostate cancer. 16638864 2006
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 AlteredExpression disease BEFREE Co-transfection of cdk activating kinase (CAK), the kinase moiety of TFIIH, enhanced AR-mediated transcription in a ligand-dependent manner in human prostate cancer PC-3 and LNCaP cells, and in a ligand-independent manner in human prostate cancer DU145 cells. 10734072 2000