Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Accordingly, AKT1 is mutated and AKT2 is amplified in some cases of breast cancer and AKT isoforms are associated with overall survival and therapy response in an isoform-specific manner.
|
31752925 |
2019 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells.
|
31357505 |
2019 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
PM were loaded with a siRNA against AKT2, an important oncogene involved in breast cancer tumorigenesis, with a special role in CSC malignancy.
|
29667444 |
2018 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins.
|
28287129 |
2017 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
The assays are able to quantify AKT1 and AKT2 from breast cancer and colon cancer cell lines and flash-frozen tumor lysates with a linear range of 0.05-2.0 fmol/μg of total lysate protein and with coefficients of variation < 15%.
|
28853539 |
2017 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
AKT2 was overexpressed in BC specimens, and its expression levels were much higher in ERα positive cancer tissues than those ERα negative cancer tissues.
|
27175587 |
2016 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, AKT2 is also exclusively required for the maintenance and survival of other PTEN-deficient solid tumors, including breast cancer and glioblastoma.
|
24838891 |
2014 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Akt2, ZEB2 and Snail were measured to clarify the underlying mechanisms of COX-2 on EMT; COX-2 may modulate EMT of breast cancer by regulating these factors.
|
25520137 |
2014 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest that IGFBPs interfere with the E2-induced activation of the Akt/PKB-pathway and prevent full hormone-dependent activation of ERα and breast cancer cell growth in an IGF- and IGF-IR-independent manner.
|
23499909 |
2013 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
AKT1 and AKT2 kinases have been shown to play opposite roles in breast cancer migration and invasion.
|
22809628 |
2012 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our data, thus, raises the possibility that Akt2 can be an effective anticancer target for the control of (breast) cancer.
|
21297943 |
2011 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer.
|
21203579 |
2010 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
CTD_human |
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.
|
19075277 |
2009 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel.
|
17332325 |
2007 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer.
|
14681726 |
2004 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Akt2: a role in breast cancer metastasis.
|
14680486 |
2004 |
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
Dysregulated PTEN-PKB and negative receptor status in human breast cancer.
|
12569575 |
2003 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival.
|
12032855 |
2002 |
Malignant neoplasm of breast
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
|
12244303 |
2002 |
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.
|
11507039 |
2001 |
Malignant neoplasm of breast
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The difference in the incidence of AKT2 alterations in ovarian and breast cancer suggests a specific role for this gene in ovarian oncogenesis.
|
7657393 |
1995 |
Malignant neoplasm of breast
|
0.600 |
GenomicAlterations
|
disease |
CGI |
|
|
|