|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Breast Carcinoma
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.700 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Effect of natural beta-interferon on estrogen receptor mRNA of breast cancer cells.
|
1295449 |
1993 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Previous reports indicate that the two-allele ER PvuII polymorphism could be associated with ER expression in breast cancer (Hill et al., Cancer Res., 49: 145-148, 1989) as well as with patient age at time of tumor diagnosis (Parl et al., Breast Cancer Res.Treat., 14: 57-64, 1989).
|
1345763 |
1992 |
|
Breast Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Various types of ER variants have been found in breast cancer biopsies and breast cancer cell lines.
|
1362141 |
1992 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
There was a significantly higher expression of IGFBP-3 mRNA in ER-negative breast carcinoma specimens when compared to the ER-positive specimens.
|
1381277 |
1992 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The ER+ T61 xenograft was established from a primary breast cancer and has been continually passaged in athymic mice.
|
1421423 |
1992 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We found that some progestins used in OC were able to stimulate the growth of estrogen receptor-positive (ER+) MCF-7 and T47DA18 human breast cancer cells but not ER- MDA-MB-231, BT-20, and T47DC4 human breast cancer cells.
|
1423300 |
1992 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In order to better understand the structural requirements for effective high affinity binding of estrogens and antiestrogens by the human estrogen receptor (ER), a comparative study was undertaken in which we examined: 1) native ER from the MCF-7 ER-positive human breast cancer cell line; 2) full length ER expressed in yeast; 3) the ER hormone binding domain (amino acid residues 302-595) expressed in yeast; 4) a bacterially expressed protein A fusion product encoding a truncated ER (amino acid residues 240-595); and 5) a synthetic peptide encompassing amino acids 510-551 of the ER.
|
1495491 |
1992 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The relationship of estrogen receptor status to DNA ploidy in breast cancer.
|
1498488 |
1992 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Effect of sodium butyrate on estrogen receptor and epidermal growth factor receptor gene expression in human breast cancer cell lines.
|
1517234 |
1992 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Data from these cell lines suggest that human breast cancer progression results first in the loss of ER, and subsequently in VIM acquisition, the latter being associated with increased metastatic potential through enhanced invasiveness.
|
1537883 |
1992 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The glutathione S-transferase pi gene (GST pi) is highly expressed in estrogen receptor negative (ER-) but not expressed in ER+ human breast cancer cell lines.
|
1587835 |
1992 |
|
Breast Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The cDNAs for variant estrogen receptor (ER) mRNAs previously identified in human breast cancer biopsy samples have been cloned and characterized.
|
1603086 |
1992 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Studies on estrogen receptor (ER)-positive human breast cancer cell lines have shown that estrogen treatment positively modulates the expression of the genes encoding transforming growth factor-alpha (TGF alpha), 52-kDa cathepsin-D, and pS2.
|
1664044 |
1991 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factor binding protein secretion by breast carcinoma cell lines: correlation with estrogen receptor status.
|
1701124 |
1990 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We have examined the ability of estradiol (E2) to regulate the expression of three mRNAs [for pS2, progesterone receptor (PR), and estrogen receptor (ER)], known to be under E2 regulation in the parental E2 growth-responsive MCF-7 cells, in an E2 growth-independent MCF-7 K3), previously isolated from the parental estrogen-dependent MCF-7 K1 human breast cancer cells after long term growth in vitro in the absence of estrogen, acquired estrogen-independent growth in vitro as well as the ability to form tumors in nude mice in vivo without estrogen.
|
1722871 |
1991 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
It is fairly well accepted that the presence of estrogen receptor (ER) and progesterone receptor (PgR) identifies breast cancer patients with a lower risk of relapse and better overall survival.
|
1728420 |
1992 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We propose the sequential determination of estrogen receptor (ER) status and DNA ploidy on the same smear obtained from a fine needle biopsy of a breast carcinoma, since both parameters seem to reflect properties associated with tumor behaviour and biological aggressiveness.
|
1756266 |
1991 |
|
Breast Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Incidence of an estrogen receptor polymorphism in breast cancer patients.
|
1756270 |
1991 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The effects of recombinant gamma interferon (IFN gamma) on proliferation, estrogen-receptor (ER) content, mRNA level and protein secretion of a breast cancer estrogen-induced protein pS2/BCEI were investigated in two human breast cancer cell lines, ZR75-1 and T47D.
|
1763658 |
1992 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The cytotoxic effect of a combination of interferons (type I and II) and tumor necrosis factor (TNF), with an antiestrogenic drug, tamoxifen (TAM), was investigated in the estrogen receptor positive human breast carcinoma cell line, MCF-7.
|
1764697 |
1991 |
|
Breast Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Estrogen receptor variants in clinical breast cancer.
|
1779964 |
1991 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Experiments were undertaken to characterize mRNAs coding for the estrogen receptor (ER) in the human breast cancer cell line T47D.
|
1779972 |
1991 |