|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Breast Carcinoma
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.700 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Flow cytometry of breast carcinoma: I. Relation of DNA ploidy level to histology and estrogen receptor.
|
7272940 |
1981 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Flow cytometry of breast carcinoma: II. Relation of tumor cell cycle distribution to histology and estrogen receptor.
|
7272941 |
1981 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In 46 cases of invasive ductal mammary carcinoma the relationship between estrogen receptor (ER) content and ploidy was investigated.
|
6288225 |
1982 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The relationship between family history, exposure to exogenous hormones, and estrogen receptor protein in breast cancer.
|
6839301 |
1983 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The induction of both pNR-1 and pNR-2 requires similar physiological concentrations of estradiol and is near maximal at 10(-10) M. An increase in the levels of the RNAs is seen after 30 min of estrogen treatment, but pNR-1 reaches its maximal concentration faster than pNR-2. pNR-1 and pNR-2 were not expressed in all human breast cancer cell lines tested. pNR-1 was expressed and regulated by estrogen in the estrogen receptor-positive cell lines, MCF-7, T-47D, and ZR 75, whereas pNR-2 was not expressed in the T-47D cell line. pNR-1 and pNR-2 were not detected in two estrogen receptor-negative cell lines (BT20 and HBL 100).
|
2430688 |
1986 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
This finding suggests that different causal mechanisms operate for these two types of breast cancer and supports the hypothesis that an early first birth protects against breast cancer by reducing the level of ERs in the mammary epithelial cells from which carcinomas develop.
|
3463818 |
1986 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Sixty-one % of these tumors had detectable PIP mRNA; a positive correlation (r = 0.52; P less than 0.01) was found between PIP mRNA levels in breast biopsy samples and estrogen receptor content, a known prognostic indicator in human breast cancer.
|
3607757 |
1987 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Northern blot analysis revealed a 6.4- and 3.7-kilobase species in ER-positive tumors and also in the human breast cancer cell line MCF-7.
|
3677099 |
1987 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We show here that the absence of estrogen receptor expression in human breast cancer cell lines is associated with higher levels of functional EGF receptor protein and mRNA.
|
3502607 |
1987 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The estrogen receptor (ER)-positive human breast cancer cell line T 47D exhibited genetic instability under cell culture conditions which maintained almost continuous exponential growth.
|
3390830 |
1988 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The effects of estradiol (E2) on c-myc proto-oncogene expression were studied in the estrogen receptor (ER)-positive human breast cancer cell line, MCF-7.
|
3290209 |
1988 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We have used MCF-7, the human breast cancer cell line, which is estrogen receptor-positive, and the HeLa cell line, which is estrogen receptor-negative, to study the mechanisms by which estrogen induces prolactin gene transcription.
|
3224823 |
1988 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer.
|
2842775 |
1988 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In estrogen-receptor-positive human breast cancer cell lines (MCF7, ZR75-1), estrogens specifically increase the secretion into the culture medium of a 52,000 Da (52K) glycoprotein and stimulate cell proliferation.
|
3145027 |
1988 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We have examined the effects of reversibly and irreversibly binding estrogenic and antiestrogenic ligands for the estrogen receptor on pS2 RNA accumulation in MCF-7 human breast cancer cells and on pS2-chloramphenicol acetyl transferase (CAT) fusion gene expression in transfected MCF-7 cells.
|
2460749 |
1988 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The present results show that p21 expression in human breast cancer could be a marker of tumor aggressiveness and might thus improve the predictive power of known prognostic factors such as estrogen receptor and nodal status.
|
3058236 |
1988 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Secreted growth factors from estrogen receptor-negative human breast cancer do not support growth of estrogen receptor-positive breast cancer in the nude mouse model.
|
3167228 |
1988 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Variant estrogen receptor mRNA species detected in human breast cancer biopsy samples.
|
2725532 |
1989 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Increased expression of the glutathione S-transferase (GST; E.C.2.5.1.18) pi class isozyme is associated with both malignant transformation and drug resistance, as well as with decreased estrogen receptor content in breast cancer.
|
2747627 |
1989 |
|
Breast Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
These data support the view that ER and EGR-R gene expression is inversely regulated in human breast cancer and describe for the first time an inhibitory effect of a phorbol ester on steroid hormone receptor gene expression.
|
2751660 |
1989 |
|
Breast Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In estrogen receptor-positive (ER+) breast carcinoma, estrogens and host hormonal modulatory mechanisms stimulate production and release of epithelial growth (EGF) and platelet-derived growth factors (PDGF).
|
2535880 |
1989 |
|
Breast Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Genomic DNA analysis of the estrogen receptor gene in breast cancer.
|
2575000 |
1989 |