|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied the significance of BsmI restriction enzyme polymorphism of the vitamin D receptor (VDR) gene and the XbaI and PvuII polymorphisms of the estrogen receptor (ER) gene in patients with type 2 diabetes (n=49), android type obesity with normal carbohydrate metabolism (n=29) and healthy controls (n=138).
|
11275948 |
2001 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Genotypes for ACE, GCK, and ESR1 may prove reliable for the assessment of genetic factors for obesity.
|
17016614 |
2006 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
23 ESR1 and 11 ESR2 tag-SNPs, covering most of the common haplotype variation in each gene according to HAPMAP data, were analysed by Chi2 for association with obesity in a cohort comprising 705 adults with severe obesity and 402 lean individuals.
|
18053221 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
It appears likely that ESR1 contributes to type 2 diabetes and CVD risk via pleiotropic effects, leading to insulin resistance, a poor lipid profile, and obesity.
|
17513703 |
2007 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
To evaluate the relationship between obesity and the ratio of estrogen receptor subtypes (ERalpha/ERbeta) in adipose tissues in pre- and postmenopausal women, we measured the anthropometric indices of 31 premenopausal women and 12 postmenopausal women.
|
17509633 |
2007 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To determine whether oestrogen receptor (ER)alpha messenger RNA (mRNA) levels or single nucleotide polymorphisms (SNPs) are associated with obesity in Swedish women.
|
17224934 |
2007 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The rs2234693 C allele of ESR1 and its associated genotypes and haplotypes were inversely and consistently associated with obesity.
|
19375130 |
2009 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families.
|
19960008 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene.
|
20667977 |
2010 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
BMI was positively associated with all-cause mortality for women diagnosed at age > or =50 years with ER-positive tumors (compared with normal-weight women, HR for overweight = 1.39, 95% CI: 0.90-2.15; HR for obese = 1.77, 95% CI: 1.11-2.82).
|
20140702 |
2010 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
RGD |
Here we investigated the role of ER alpha and ER beta in a model of nutrition induced obesity.
|
22230815 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In multiple public expression data sets of breast cancers (representing > 1,500 patients), manifestation of the obesity signature patterns correlated with manifestation of a gene signature for IGF signaling and (to a lesser extent) with lower levels of estrogen receptor.
|
21750966 |
2012 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Since obesity and osteoporosis present a high genetic predisposition and polymorphisms of IL-6, IL6R, LRP5, ESR1 and SP7 may influence the risk of both diseases, the aim of this study was to analyze the possible association of polymorphisms in these genes, as well as their haplotypes, with BMD variations in postmenopausal Mexican-Mestizo women with grade 2 or grade 3 obesity.
|
23891823 |
2013 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Obesity increases the risk of cancer death among postmenopausal women with estrogen receptor-positive (ER+) breast cancer, but the direct evidence for the mechanisms is lacking.
|
24957076 |
2014 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Variants of estrogen receptor α (ERα) have been associated with obesity, dyslipidemia, diabetes and blood pressure.
|
24140101 |
2014 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Considering that inactivation of estrogen receptor (ER)α promotes obesity and metabolic dysfunction in women and female mice, understanding the mechanisms and tissue-specific sites of ERα action to combat metabolic-related disease, including BrCA, is of clinical importance.
|
25468909 |
2015 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that adipocytes can modify breast cancer cell ER gene expression through hypoxia and also can promote EMT processes in breast cancer cells, supporting an important role of obesity in aggressive breast cancer development.
|
25823469 |
2015 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Obesity was significantly associated with differential methylation (FDR q < 0.05) in just two gene loci in breast tumor tissue overall and in 21 loci among ER-positive tumors.
|
25583948 |
2015 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity is associated with a worse breast cancer prognosis, particularly in estrogen receptor alpha (ERα) positive, postmenopausal patients.
|
25476497 |
2015 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity is an established risk factor for postmenopausal breast cancer (BCa), insulin resistance, and vitamin D deficiency, and all contribute to increased synthesis of mammary estrogens, the drivers of estrogen receptor-positive (ER+) BCa growth.
|
26817629 |
2016 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Herein, we found that BMP4 deficiency in white adipose tissue (WAT) increased the estrogen receptor α (ERα) level and its signaling, which prevented adult female mice from developing high fat diet (HFD)-induced obesity and insulin resistance; estrogens depletion up regulated BMP4 expression to overcome overt adiposity and impaired insulin sensitivity with aging, and failure of BMP4 regulation due to genetic knockout led to more fat gain in aged female mice.
|
27522322 |
2016 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The data suggest a possibility that dietary <i>S</i>-equol could be an alternative to hormone replacement therapy for the prevention of hyperphagia and obesity with a lower risk of adverse effects induced by ER-α stimulation.
|
29097993 |
2017 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, it is speculated that such ESR1 epigenetic changes may be influenced or shaped by obesity and reproductive history-related factors before and during breast carcinogenesis.
|
28708432 |
2017 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Selective Activation of Estrogen Receptor α Activation Function-1 Is Sufficient to Prevent Obesity, Steatosis, and Insulin Resistance in Mouse.
|
28502695 |
2017 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The insulin signaling network is influenced by obesity and may interact with the estrogen receptor α (ERα) signaling.
|
29234306 |
2017 |