|
Inflammatory Bowel Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Luciferase assays confirmed that ETS variant 5 (ETV5) was a functional target of miR-219a-5p and ETV5 expression was significantly increased in the inflamed intestinal mucosa and PB-CD4<sup>+</sup> T cells from IBD patients.
|
31628427 |
2020 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigate a transcription factor of the ETS-family, ETV5, as a putative effector of FGFR3 signalling in bladder cancer.
|
30952872 |
2019 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigate a transcription factor of the ETS-family, ETV5, as a putative effector of FGFR3 signalling in bladder cancer.
|
30952872 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that EVT5 may be a potential new diagnostic and prognostic marker in CRC and that targeting ETV5 might be a potential therapeutic option for inhibiting CRC angiogenesis.
|
30650178 |
2019 |
|
Endocardial Cushion Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
We predicted that these OFT-atrioventricular canal pathways were regulated by a large number of TFs actively expressed at the OFT-atrioventricular canal cardiomyocytes, with the prediction supported by motif enrichment analysis, including 10 TFs that have not been previously associated with cardiac development (eg, Etv5, Rbpms, and Baz2b).
|
31322043 |
2019 |
|
Lymphatic Metastasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we initially demonstrated that ETS translocation variant 5 (ETV5) is abnormally upregulated in colorectal cancer (CRC), is positively correlated with CRC tumor size, lymphatic metastasis and tumor node metastasis (TNM) stage and indicates shorter survival and disease-free survival in CRC patients.
|
30650178 |
2019 |
|
Retinitis Pigmentosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
To report the prevalence of treatable complications (cystoid macular oedema, CME; epiretinal membrane, ERM and cataract) in patients with retinitis pigmentosa (RP).
|
30291136 |
2019 |
|
Cataract
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with ERM and cataract/pseudophakia were less likely to also have CME (OR 0.19, 95% CI 0.09 to 0.40 and OR 0.37, 95% CI 0.16 to 0.84, respectively).
|
30291136 |
2019 |
|
Solid Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Ezrin is a member of the ezrin-radixin-moesin (ERM) protein family and has been shown to be associated with poor prognosis in patients with a variety of solid tumors.
|
31376222 |
2019 |
|
Regular astigmatism - corneal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with age-related cataract, regular corneal astigmatism less than 1.25 diopters (D) and a clinically significant vitreomacular pathology (epiretinal membrane [ERM], macular hole, or vitreomacular traction [VMT] syndrome) who had combined phacovitrectomy with internal limiting membrane peeling were enrolled.
|
30309772 |
2019 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigate a transcription factor of the ETS-family, ETV5, as a putative effector of FGFR3 signalling in bladder cancer.
|
30952872 |
2019 |
|
Atrioventricular Septal Defect
|
0.010 |
Biomarker
|
disease |
BEFREE |
We predicted that these OFT-atrioventricular canal pathways were regulated by a large number of TFs actively expressed at the OFT-atrioventricular canal cardiomyocytes, with the prediction supported by motif enrichment analysis, including 10 TFs that have not been previously associated with cardiac development (eg, Etv5, Rbpms, and Baz2b).
|
31322043 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
ETS variant 5 promotes colorectal cancer angiogenesis by targeting platelet-derived growth factor BB.
|
30650178 |
2019 |
|
Acute pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By using a mouse model of acute pancreatitis and three dimensional organoid culture of primary pancreatic ductal cells, we herein characterize the Ets-transcription factor Etv5 as a pivotal regulator of ductal cell identity and ADM that acts upstream of Sox9 and is essential for Sox9 expression in ADM. Loss of Etv5 is associated with increased severity of acute pancreatitis and impaired ADM formation leading to delayed tissue regeneration and recovery in response to injury.
|
29532564 |
2018 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Using the betweenness centrality measure, we identified Etv5 as a potential tissue-level regulator in murine neurofibromatosis type 1 (Nf1) low-grade brain tumors (optic gliomas).
|
29787563 |
2018 |
|
Herpes Simplex Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Furthermore, our results revealed the highly conserved mechanism of MED25 interaction with intrinsically unfolded acidic TADs from the transcriptional activators p53, ERM (Ets-related molecule), and herpes simplex virus protein 16 (VP16).
|
30360415 |
2018 |
|
Lymphoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The Leydig and Sertoli cells distribution and Leydig cells steroidogenic activity, expression of glial cell line-derived neurotrophic factor (GDNF), proto-oncogene Rearranged during Transfection (c-RET) receptor, Ets variant gene 5 (Etv5) and B-cell chronic lymphocytic leukemia (CLL)/lymphoma 6, member B (Bcl-6b) at mRNA and protein levels were analyzed.
|
29496177 |
2018 |
|
Macular Edema, Cystoid
|
0.010 |
Biomarker
|
disease |
BEFREE |
Single IVD could significantly decrease macular edema and improve visual outcome for eyes with persistent long-term macular edema after macular ERM removal and the effect can be sustained as long as 6 months after the initial injection.
|
30693103 |
2018 |
|
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that ETV5 is regulated both at the protein and mRNA levels upon ALK activation or inhibition in neuroblastoma cell lines and that this regulation precedes RET modulation.
|
29321660 |
2018 |
|
Neurofibromatosis 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using the betweenness centrality measure, we identified Etv5 as a potential tissue-level regulator in murine neurofibromatosis type 1 (Nf1) low-grade brain tumors (optic gliomas).
|
29787563 |
2018 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis.
|
29532564 |
2018 |
|
Proliferative diabetic retinopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The proteome of 34 vitreous humor samples (dry AMD: n = 6; nAMD: n = 10; proliferative diabetic retinopathy [PDR]: n = 9; epiretinal membrane [ERM]: n = 9) was analyzed by liquid chromatography coupled mass spectrometry.
|
30025106 |
2018 |
|
Neoplasm, Residual
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We conclude that our novel metric - ERM-D8 - based on time-series GEP after 8 days of remission-induction therapy can independently predict relapse even after adjusting for NCI risk, genetics, Day 8 peripheral blood response and MRD.
|
29808917 |
2018 |
|
Macular retinal edema
|
0.010 |
Biomarker
|
disease |
BEFREE |
Single IVD could significantly decrease macular edema and improve visual outcome for eyes with persistent long-term macular edema after macular ERM removal and the effect can be sustained as long as 6 months after the initial injection.
|
30693103 |
2018 |
|
Adult Pilocytic Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
As such, the expression of Etv5 and Etv5 target genes were increased in multiple independently-generated mouse optic glioma models relative to non-neoplastic (normal healthy) optic nerves, as well as in the cognate human tumors (pilocytic astrocytoma) relative to normal human brain.
|
29787563 |
2018 |