|
Malignant neoplasm of prostate
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
We have investigated ETV1, ETV4, and ETV5 overexpression, with or without PTEN loss, and their association with grade group (GG), pathological stage, focality, and PSA recurrence in PrCa.
|
31016435 |
2019 |
|
Malignant neoplasm of prostate
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Further pilot experiments demonstrated that the in vitro assays are robust for ERG, ETV1, and ETV5, three of the ETS transcription factors that are overexpressed in prostate cancer.
|
30204534 |
2019 |
|
Malignant neoplasm of prostate
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the prostate cancer-related oncogenic E26 transformation-specific (ETS) transcription factors, ETV1, ETV4, and ETV5, were required for TAZ gene transcription in PC3 prostate cancer cells.
|
28408625 |
2017 |
|
Malignant neoplasm of prostate
|
0.390 |
Biomarker
|
disease |
CTD_human |
An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer.
|
27783944 |
2016 |
|
Malignant neoplasm of prostate
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Novel RNA hybridization method for the in situ detection of ETV1, ETV4, and ETV5 gene fusions in prostate cancer.
|
25203299 |
2014 |
|
Malignant neoplasm of prostate
|
0.390 |
Biomarker
|
disease |
BEFREE |
GeneChip Affymetrix exon 1.0 ST arrays were used for expression profiling of ERG, erythroblast transformation-specific (ETS) variant gene 1 (ETV1), ETV4 and ETV5 genes in 67 prostate cancer tissue specimens.
|
23578236 |
2013 |
|
Malignant neoplasm of prostate
|
0.390 |
Biomarker
|
disease |
BEFREE |
Likewise, chromosomal rearrangements of the ETV1, ETV4 or ETV5 gene occur in prostate tumors and are thought to be one of the major driving forces in the genesis of prostate cancer.
|
22425584 |
2012 |
|
Malignant neoplasm of prostate
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
The proto-oncogenes ETV1, ETV4 and ETV5 encode transcription factors in the E26 transformation-specific (ETS) family, which includes the most frequently rearranged and overexpressed genes in prostate cancer.
|
21572435 |
2011 |
|
Malignant neoplasm of prostate
|
0.390 |
Biomarker
|
disease |
BEFREE |
Recurrent gene fusions involving E26 transformation-specific (ETS) transcription factors ERG, ETV1, ETV4, or ETV5 have been identified in 40% to 70% of prostate cancers.
|
18794152 |
2008 |
|
Malignant neoplasm of prostate
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Here, we identify ETV5 as the fourth ETS family member involved in recurrent gene rearrangements in prostate cancer.
|
18172298 |
2008 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer.
|
27783944 |
2016 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
Likewise, chromosomal rearrangements of the ETV1, ETV4 or ETV5 gene occur in prostate tumors and are thought to be one of the major driving forces in the genesis of prostate cancer.
|
22425584 |
2012 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
LHGDN |
Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
|
18172298 |
2008 |
|
Obesity
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
While the majority of these were located in intergenic regions or in a locus on chromosome 16 near and in the NPIPL1 and SH2B1 genes (best SNP: rs4788101, p = 2.1E-24), five were located in the ETV5 gene (best SNP: rs1516725, p = 1E-24), which was previously associated with both BD and obesity, and one in the RPGRIP1L gene (rs1477199, p = 5.7E-09), which was also included in the Signaling by Hedgehog pathway.
|
31754094 |
2019 |
|
Obesity
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Recently, ETV5 (ets variant gene 5) has been associated with obesity and food intake control mechanisms in mammals.
|
28041791 |
2017 |
|
Obesity
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Two obesity susceptibility loci in LYPLAL1 and ETV5 independently associated with childhood hypertension in Chinese population.
|
28645872 |
2017 |
|
Obesity
|
0.160 |
AlteredExpression
|
disease |
BEFREE |
The Drosophila ETV5 homologue Ets96B regulates the expression of cellular systems with links to obesity and behaviour, including the expression of a conserved endoplasmic reticulum molecular chaperone complex known to be neuroprotective.
|
27280443 |
2016 |
|
Obesity
|
0.160 |
Biomarker
|
disease |
BEFREE |
AAV-mediated gene transfer of the obesity-associated gene Etv5 in rat midbrain does not affect energy balance or motivated behavior.
|
24710089 |
2014 |
|
Obesity
|
0.160 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Obesity
|
0.160 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Obesity
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1.
|
21796137 |
2011 |
|
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
|
30698716 |
2019 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
|
31152163 |
2019 |
|
Glomerular Filtration Rate
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program.
|
31451708 |
2019 |