Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Regarding the uncertainty of the exact cause of the acute lymphocytic leukemia (ALL) caused by ETV6-RUNX1t(12;21) translocation, correcting genes of the ETV6 and RUNX1 in ETV6/RUNX1 fusion gene simultaneously on chromosome 12 may be effective in reducing leukemia malignancy.
|
31602594 |
2020 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
This study was aimed to explore the METTL3 and METTL14 expressions in children with ETV6/RUNX1(E/R)-positive acute lymphoblastic leukemia (ALL) and investigate the relation between the METTL3 and METTL14 expressions with clinical features.
|
31429529 |
2019 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Common CNAs involved CDKN2A/2B (30.3%), IKZF1 (27.3%), PAX5 (9.1%), RB1 (9.1%), BTG1 (6.7%), and ETV6 (6.7%), which regulate cell cycle, B lymphopoiesis, or act as tumor suppressors in ALL.
|
31112375 |
2019 |
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We herein describe novel risk loci for B-ALL at 9q21.31 (rs76925697, P = 2.11 × 10<sup>-8</sup>), for high-hyperdiploid ALL at 5q31.1 (rs886285, P = 1.56 × 10<sup>-8</sup>) and 6p21.31 (rs210143 in BAK1, P = 2.21 × 10<sup>-8</sup>), and ETV6-RUNX1 ALL at 17q21.32 (rs10853104 in IGF2BP1, P = 1.82 × 10<sup>-8</sup>).
|
31767839 |
2019 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Discontinuation of L-asparaginase and poor response to prednisolone are associated with poor outcome of ETV6-RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia.
|
30689137 |
2019 |
Acute lymphocytic leukemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia.
|
30381299 |
2019 |
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The ETV6-ABL1 fusion is a rare genetic aberration classified as Philadelphia chromosome-like high-risk B-cell precursor acute lymphoblastic leukemia.
|
30028819 |
2019 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
A high proportion of ETV6-RUNX1-positive ALL relapses (40%) in our cohort showed a poor response to induction treatment at relapse, and therefore had an indication for hematopoietic stem cell transplantation, demonstrating the need of accurate identification of this subgroup.
|
31034759 |
2019 |
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The <i>ERG</i> risk genotype was underrepresented in ALL with the <i>ETV6-RUNX1</i> fusion (<i>P</i> < .0005) but enriched in the <i>TCF3-PBX1</i> subtype (<i>P</i> < .05).
|
30510082 |
2019 |
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The most frequently occurring genetic abnormality in pediatric B-lymphocyte-lineage acute lymphoblastic leukemia is the t(12;21) chromosomal translocation that results in a ETV6-RUNX1 (also known as TEL-AML1) fusion gene.
|
30986496 |
2019 |
Acute lymphocytic leukemia
|
0.200 |
AlteredExpression
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disease |
BEFREE |
BCR-ABL1, TCF3-PBX1, KMT2A-AFF1 and ETV6-RUNX1 were more frequent in B-ALL.
|
30125757 |
2018 |
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Finally, we reviewed the literature for ETV6 germline aberrations and predispositions to ALL.
|
29034503 |
2018 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
The multiplex ligation-dependent probe amplification (MLPA) method was used to detect the copy number alterations (CNAs) of IKAROS family zinc finger 1 (<i>IKZF1</i>), paired box 5 (<i>PAX5</i>), ETS variant 6 (<i>ETV6</i>), RB transcriptional corepressor 1 (<i>RB1</i>), BTG anti-proliferation factor 1 (<i>BTG1</i>), early B-cell factor 1 (<i>EBF1</i>), cyclin dependent kinase inhibitor 2A/2B (<i>CDKN2A/2B</i>) and cytokine receptor like factor 2 (<i>CRLF2</i>) genes in 87 adults with acute lymphoblastic leukemia (ALL) in China.
|
29552179 |
2018 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Two novel fusion genes, AIF1L-ETV6 and ABL1-AIF1L, result together with ETV6-ABL1 from a single chromosomal rearrangement in acute lymphoblastic leukemia with prenatal origin.
|
29726059 |
2018 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Phosphatase of regenerating liver-3 <i>(PRL-3/PTP4A3)</i> is upregulated in multiple cancers, including BCR-ABL1- and ETV6-RUNX-positive acute lymphoblastic leukemia (ALL).
|
29423065 |
2018 |
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Here, we report a 14-year-old female BCP-ALL patient with ETV6-ABL1 fusion combined with monosomy 7.
|
29177615 |
2018 |
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
NRAS mutations were associated with a higher frequency of hyperdiploidy (P = 0.01) and lower frequency of ETV6-RUNX1 (P < 0.01), whereas KRAS mutations were associated with younger age (P < 0.01), a higher frequency of KMT2A rearranged (P < 0.01) but no significant difference if infants with ALL were excluded, and inferior event-free survival (66.6% vs. 80.5%, P = 0.04).
|
28853218 |
2018 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.
|
29290585 |
2018 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Second, in a small fraction of these cases, the postnatal acquisition of secondary genetic changes (primarily V(D)J recombination-activating protein (RAG) and activation-induced cytidine deaminase (AID)-driven copy number alterations in the case of ETS translocation variant 6 (ETV6)-runt-related transcription factor 1 (RUNX1)<sup>+</sup> ALL) drives conversion to overt leukaemia.
|
29784935 |
2018 |
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Minimal residual disease monitoring in childhood B lymphoblastic leukemia with t(12;21)(p13;q22); ETV6-RUNX1: concordant results using quantitation of fusion transcript and flow cytometry.
|
28004528 |
2017 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
The t(12;21) (p13;q22) chromosomal translocation resulting in the <i>ETV6/RUNX1</i> fusion gene is the most frequent structural cytogenetic abnormality in children with acute lymphoblastic leukemia (ALL).
|
29029492 |
2017 |
Acute lymphocytic leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
It has, however, been possible to backtrack this process through molecular analysis of appropriate clinical samples: (i) leukaemic clones in monozygotic twins that are either concordant or discordant for ALL; (ii) archived neonatal blood spots or Guthrie cards from individuals who later developed leukaemia; and (iii) stored, viable cord blood cells.Here, we outline our studies on the aetiology and pathology of childhood ALL that provide molecular evidence for a monoclonal, prenatal origin of ETV6-RUNX1+ leukaemia in monozygotic identical twins.
|
28299660 |
2017 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
<i>ETV6/RUNX1</i> (+) ALL may be heterogeneous in terms of prognosis, and variables such as MRD at end ofremission induction or additional structural abnormalities of 12p could define a subset of patients who are likely to have poor outcome.
|
27506214 |
2017 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
In conclusion, we show that ETV6/RUNX1-like ALL is associated with CD27<sup>pos</sup> /CD44<sup>low-neg</sup> immunophenotype and identify ARPP21 deletions to contribute to its specific genomic profile enriched for ETV6 and IKZF1 lesions.
|
28395118 |
2017 |
Acute lymphocytic leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
All but one of the cases of ETV6-ABL1 acute lymphoblastic leukemia were classified as BCR-ABL1-like by a standardized assay.
|
27229714 |
2016 |