MECOM, MDS1 and EVI1 complex locus, 2122

N. diseases: 191; N. variants: 57
Disease: Solid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.040 AlteredExpression phenotype BEFREE However, aberrantly high expression of EVI1 has potent oncogenic properties and confers poor prognosis and chemo-resistance in leukemia and solid tumors. 29939287 2018
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.040 Biomarker phenotype BEFREE In blood system, MECOM is considered an oncogene, but in solid tumors it has both oncogenic and tumor suppressor activities. 27620344 2017
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.040 AlteredExpression phenotype BEFREE These results may provide us with novel therapeutic approaches to conquer the poor prognosis associated with Evi1-activated leukemia or other solid tumors with high Evi1 expression. 21795762 2011
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.040 Biomarker phenotype BEFREE EVI-1 is overexpressed in ovarian cancer compared with normal ovaries, suggesting a role for EVI-1 in solid tumour carcinogenesis or progression. 8932329 1996