|
Intellectual Disability
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Decreased antibody level in blood
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Although there is still no definitive evidence that EXTL3 is a tumor suppressor gene for CRC, these data suggest that inactivation of the EXTL3 gene may at least offer a selective growth advantage for some CRC cell lines.
|
10536173 |
1999 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Exostoses like-3 (EXTL3) is a putative tumour suppressor gene but its involvement in colorectal cancer (CRC) is unclear.
|
18543267 |
2008 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
For cancer gene therapy, a recombinant adenovirus serotype 5 named RPR/INGN201 has been constructed by susbtitution of the E1 region with human tumor suppressor gene p53.
|
11461012 |
2001 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
We have examined the effects of a replication-defective adenovirus encoding p53 (RPR/INGN 201 [Ad5CMV-p53]; Adp53), alone or in combination with the breast cancer therapeutic doxorubicin (Adriamycin), to suppress growth and induce apoptosis in breast cancer cells in vitro.
|
11339893 |
2001 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
In view of its putative tumor suppressor function, the EXTL3 gene can be considered a candidate gene for the breast cancer locus on chromosome 8p12-p22.
|
9479495 |
1998 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
We identified a gene termed hEXT1L/EXTR1/EXTL3 (hEXT1L hereinafter) that was mapped to chromosome bands 8p12-p21 where frequent LOHs of this region was reported in breast cancer.
|
10427123 |
1999 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We have examined the effects of a replication-defective adenovirus encoding p53 (RPR/INGN 201 [Ad5CMV-p53]; Adp53), alone or in combination with the breast cancer therapeutic doxorubicin (Adriamycin), to suppress growth and induce apoptosis in breast cancer cells in vitro.
|
11339893 |
2001 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We identified a gene termed hEXT1L/EXTR1/EXTL3 (hEXT1L hereinafter) that was mapped to chromosome bands 8p12-p21 where frequent LOHs of this region was reported in breast cancer.
|
10427123 |
1999 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In view of its putative tumor suppressor function, the EXTL3 gene can be considered a candidate gene for the breast cancer locus on chromosome 8p12-p22.
|
9479495 |
1998 |
|
syphilis infection
|
0.030 |
Biomarker
|
disease |
BEFREE |
During 2012-2014, we screened 1625 MSM from Lima, Peru, for syphilis infection and enrolled 370 MSM with symptomatic primary or secondary syphilis (n=58) or asymptomatic latent syphilis diagnosed by serology (rapid plasma reagin, RPR, and Microhemagglutination assay for Treponema pallidum antibody; n=312).
|
29970355 |
2018 |
|
syphilis infection
|
0.030 |
Biomarker
|
disease |
BEFREE |
UAI was assessed via self-report and active syphilis infection was diagnosed by RPR and THPA tests.
|
29615297 |
2018 |
|
syphilis infection
|
0.030 |
Biomarker
|
disease |
BEFREE |
The primary outcome of incident syphilis infection was defined serologically as a newly positive test with positive confirmatory testing after a negative test or a 2-dilution increase in RPR titer.
|
31712815 |
2019 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Although there is still no definitive evidence that EXTL3 is a tumor suppressor gene for CRC, these data suggest that inactivation of the EXTL3 gene may at least offer a selective growth advantage for some CRC cell lines.
|
10536173 |
1999 |
|
Hereditary Multiple Exostoses
|
0.020 |
Biomarker
|
disease |
BEFREE |
Based on PCR-assisted analyses of both a human/rodent mono-chromosomal hybrid cell panel and a radiation hybrid mapping panel, EXTR1 was localized to the chromosome 8p21 region, where loss of heterozygosity has been frequently observed in various tumors, and EXTR2 was assigned to the chromosome 1p21 region, where osteopetrosis, a dominant hereditary disease of bone, has been mapped by genetic linkage analysis, implying that the protein products of these two EXT-related genes, as well as of the EXT genes, have potential tumor suppressor activity.
|
9473480 |
1998 |
|
Liver Cirrhosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
VCTE demonstrated excellent diagnostic accuracy for the detection of cirrhosis with an AUROC of 0.90 compared with APRI (0.83), FIB-4 (0.88), AAR (0.73) and RPR (0.85).
|
31742822 |
2020 |
|
Liver Cirrhosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, GPR does not show advantages than APRI, FIB-4 and RPR in identifying significant liver fibrosis, advanced liver fibrosis and liver cirrhosis in both HBeAg positive CHB and HBeAg negative CHB in China.
|
28819319 |
2017 |
|
Sexually Transmitted Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
From 2013 to 2014, MSM and transwomen seeking human immunodeficiency virus (HIV) or sexually transmitted infection (STI) testing and/or treatment were recruited into a 2-year observational cohort study to determine predictors of recently acquired syphilis infection (defined as a rapid plasma reagin [RPR] titer ≥1:16 and a reactive treponemal antibody test) in Lima, Peru.
|
28399798 |
2017 |
|
Sexually Transmitted Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
<b>Purpose.</b> We evaluated the Sekure rapid plasma reagin (RPR-S) (Sekisui Diagnostics) automated quantitative latex immunoturbidimetric assay performed on the SK500 clinical chemistry system for clinical appropriateness.<b>Methodology.</b> Syphilis-infected individuals and controls were recruited into a prospective cohort study conducted at a sexually transmitted infection clinic in Antwerp, Belgium.
|
28792374 |
2017 |
|
Syphilis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Of the 92 discordant samples, 9 were from the baseline visit (RPR-C titre: 1-8), which could have led to possible missed diagnoses using the RPR-S.<b>Conclusions.</b> The sensitivity and accuracy of the RPR-S test requires improvement before it can be used to diagnose syphilis and evaluate treatment efficacy in clinical practice.
|
28792374 |
2017 |
|
Syphilis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Until now only non-treponemal tests (e.g. rapid plasma reagin [RPR]) have been used to monitor syphilis activity (e.g. distinguishing between treated, untreated and repeat disease) and efficacy of treatment.
|
29629652 |
2018 |
|
Syphilis, secondary
|
0.020 |
Biomarker
|
disease |
BEFREE |
For primary syphilis, a low RPR (0-16) was correlated with a higher detection rate of TP-DNA, whereas for secondary syphilis, the higher detection rate of blood TP-DNA was correlated with higher blood RPR titers (at or beyond 32).
|
29739928 |
2018 |
|
Syphilis, secondary
|
0.020 |
Biomarker
|
disease |
BEFREE |
During 2012-2014, we screened 1625 MSM from Lima, Peru, for syphilis infection and enrolled 370 MSM with symptomatic primary or secondary syphilis (n=58) or asymptomatic latent syphilis diagnosed by serology (rapid plasma reagin, RPR, and Microhemagglutination assay for Treponema pallidum antibody; n=312).
|
29970355 |
2018 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Ad5CMVp53 (RPR/INGN 201) has previously shown promise in both patients with lung cancer and those with head and neck cancer.
|
10854146 |
2000 |