|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Factor V Leiden (FVL) and prothrombin gene (G20210A) mutations are the most common types of hereditary thrombophilias, but are usually undiagnosed because most carriers are asymptomatic.
|
15006834 |
2004 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The heterozygous 20210 G/A prothrombin genotype is associated with early venous thrombosis in inherited thrombophilias and is not increased in frequency in artery disease.
|
9409210 |
1997 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The important polymorphisms leading to inherited thrombophilia are Factor V Leiden (FVL), Prothrombin G20210A and MTHFR C677T and A1298C.
|
26135458 |
2016 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The child was also carrier of heterozygous prothrombin G20210A variant.Severe venous thromboembolism can occur in otherwise healthy children with complex inherited thrombophilia.
|
29536478 |
2018 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Codon 596 (CGG) of prothrombin is a hot spot for mutations, which constitute a new and relatively frequent cause of inherited thrombophilia.
|
27013614 |
2016 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine (1). whether the inherited thrombophilias (the factor V Leiden and prothrombin gene mutations and the methylenetetrahydrofolate reductase [C677T] polymorphism) are increased in women with "idiopathic" (normotensive) small-for-gestational-age pregnancies and/or in their babies and (2). whether fetal carriage of a thrombophilia is associated with abnormal umbilical Doppler studies.
|
12712097 |
2003 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Complete hematological work-up for hypercoagulable state revealed a heterozygous mutation of the prothrombin gene (G20210A).
|
17663298 |
2007 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Familial thrombophilia and the prothrombin 20210A mutation: association with increased thrombin generation and unusual thrombosis.
|
10070829 |
1999 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Factor V Leiden and prothrombin G20210A are the two most prevalent causes of inherited thrombophilia.
|
22562116 |
2012 |
|
Thrombophilia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In 107 asymptomatic and untreated patients with inherited syndromes associated with thrombophilia (antithrombin III, protein C and protein S deficiencies), we compared in parallel two plasma peptides which reflect activation of the common coagulation pathway: the prothrombin fragment 1 + 2 (F1 + 2) and fibrinopeptide A (FPA).
|
1535736 |
1992 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Screening for thrombophilia revealed a heterozygote 20210 G/A mutation of the prothrombin gene.Anticoagulation was initiated.
|
17342369 |
2007 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Isolated pulmonary embolism (PE) was less prevalent in patients with FVLeiden (6%) and no thrombophilia (6%) than in those with prothrombin G20210A (15%).
|
18796457 |
2010 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several recent studies have analyzed a possible effect of thrombophilia risk factors such as factor V Leiden, the prothrombin variant (allele 20210 A), and homozygosity for thermolabile methylenetetrahydrofolate reductase (MTHFR-T) on the development of ischemic stroke (IS).
|
10739378 |
2000 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The most common forms of familial thrombophilia are factor V Leiden (FVL) and prothrombin mutation (PTM).
|
23054468 |
2013 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Prothrombin gene polymorphism G20210A seems to be nonexistent in our population and AT III deficiency also appears to be low compared to other markers of thrombophilia.
|
11292195 |
2001 |
|
Thrombophilia
|
0.600 |
Biomarker
|
disease |
CTD_human |
A prospective study of the prevalence of heparin-induced antibodies and other associated thromboembolic risk factors in pediatric patients undergoing hemodialysis.
|
16628723 |
2006 |
|
Thrombophilia
|
0.600 |
Biomarker
|
disease |
RGD |
Ellagic acid-induced hypercoagulable state in animals: a potentially useful animal hypercoagulable model for evaluation of anticoagulants.
|
21232185 |
2010 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether risk factors for placental abruption because of such thrombophilias (such as carriership of factor V Leiden (FVL), prothrombin G20210A gene mutation and homozygous MTHFR C677T) might be used as a predictor for placental abruption.
|
17627684 |
2007 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Enhanced mRNA 3' end formation efficiency emerges as a novel principle causing a genetic disorder and explains the role of the F2 20210 G-->A mutation in the pathogenesis of thrombophilia.
|
11443298 |
2001 |
|
Thrombophilia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The use of coagulation activation markers (soluble fibrin polymer, TpP, prothrombin fragment 1.2, thrombin-antithrombin, and D-dimer) in the assessment of hypercoagulability in patients with inherited and acquired prothrombotic disorders.
|
11943933 |
2002 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This review of prothrombin G20210A prevalence may guide resourceful screening for identification of hereditary thrombophilia in female populations of interest with hypercoagulable states.
|
27058219 |
2016 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
It is recommended that women with a personal or strong family history of venous thromboembolism should be screened for the prothrombin mutation either before or early in pregnancy, in addition to screening for other thrombophilias.
|
10759281 |
2000 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A case-control design within a large cohort of families with thrombophilia was chosen to calculate the risk of recurrent venous thrombosis in individuals with homozygosity or double heterozygosity of factor V Leiden and/or prothrombin G20210A.
|
20368522 |
2010 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The discoveries of the factor V Leiden mutation and the prothrombin gene variant 20210 in the last decade have markedly contributed to the understanding of the molecular pathophysiology of inherited risk factors for thrombophilia.
|
12130896 |
2002 |
|
Thrombophilia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) within the genes of factor V (FV) (G1691A; exon 10), prothrombin (FII) (G20210A; 3'untranslated - region) and methylenetetrahydrofolate reductase (MTHFR) (C677T; exon 4) are associated with hypercoagulability, and systematic screening of individuals being at higher risk of thrombosis has been suggested.
|
16305681 |
2005 |