F2R, coagulation factor II thrombin receptor, 2149

N. diseases: 347; N. variants: 10
Disease: Angiogenic Switch ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.020 Biomarker disease BEFREE Deficiency of PAR2, but not of the thrombin receptor PAR1, delays spontaneous breast cancer development and the angiogenic switch in mice. 20434002 2010
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.020 Biomarker disease BEFREE This study establishes that protease signaling contributes to mammary tumor development and that PAR2, rather than the thrombin receptor PAR1, plays a crucial role in the angiogenic switch. 18757438 2008