ALDH2, aldehyde dehydrogenase 2 family member, 217

N. diseases: 337; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0394996
Disease: Acute alcoholic intoxication
Acute alcoholic intoxication 		0.020 Biomarker disease BEFREE A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the ALDH2 isozyme, which has a low apparent Km for acetaldehyde. 7180842 1982
CUI: C0394996
Disease: Acute alcoholic intoxication
Acute alcoholic intoxication 		0.020 Biomarker disease BEFREE Main effects of ALDH2*2(-) and having more friends who got drunk were associated with greater alcohol consumption. 28471244 2017
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.020 GeneticVariation disease BEFREE These results suggested that ALDH2 Glu504Lys variant could predict a worse prognosis of ACS patients. 29441687 2018
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.020 GeneticVariation disease BEFREE Our results suggest that ALDH2 mutation is a genetic risk marker for ACS, which is explained in part by alcohol consumption, inflammation and number of circulating EPCs. 21958412 2011
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.020 GeneticVariation disease BEFREE Aldehyde dehydrogenase 2 (ALDH2) Glu504Lys variant was an independent risk factor for acute coronary syndrome (ACS). 29441687 2018
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.020 GeneticVariation disease BEFREE This study aimed to investigate the association of the aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism, which exists in 30-50% of East Asians, and risk of acute coronary syndrome (ACS). 21958412 2011
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.050 Biomarker disease BEFREE To elucidate the mechanisms underlying the association of ALDH2*2 with AMI, we compared the clinical features of AMI patients with ALDH2*2 to those with wild-type ALDH2*1/*1. 27153870 2016
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.050 GeneticVariation disease BEFREE Thus, the A allele in ALDH2 gene is associated with the elevated plasma levels of hs-CRP after the onset of AMI, suggesting a higher susceptibility of the myocardium to ischemic injuries. 20467232 2010
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.050 Biomarker disease BEFREE Alda‑1, an aldehyde dehydrogenase 2 (ALDH2) agonist, has been demonstrated to reduce injury caused by acute myocardial infarction (MI) and ischemia/reperfusion. 30066916 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.050 GeneticVariation disease BEFREE Deficient variant ALDH2*2 genotype is prevalent among East Asians and is a significant risk factor for both coronary spasm and AMI through accumulation of toxic aldehydes, thereby contributing to oxidative stress, endothelial damage, vasoconstriction, and thrombosis. 31368101 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.050 AlteredExpression disease BEFREE These findings suggest that miR-28 promotes myocardial ischemia through the inhibition of ALDH2 expression in mus. miRNAs is as a probable index in identification of myocardial ischemia after acute myocardial infarction. 25807426 2015
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis 		0.020 Biomarker disease BEFREE Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, we determined the polymorphism of CD14 gene and aldehyde dehydrogenase gene 2 (ALDH 2) in 335 alcoholic patients with different organ complications i.e., cirrhosis of liver (n = 100), acute pancreatitis (n = 100), esophageal cancer (n = 82) and avascular necrosis of hip joint (AVN) (n = 53) and 194 non-alcoholic controls in a Chinese group. 16273622 2005
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis 		0.020 Biomarker disease BEFREE In conclusion, ALDH2 activation by Alda-1 has a protective effect in cerulein-induced AP by mitigating apoptosis in pancreatic acinar cells by alleviating lipid peroxidation. 31784085 2020
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.030 Biomarker phenotype BEFREE Understanding the influences of genes involved in dopamine and serotonin metabolism, such as the aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) genes, is critical for understanding addictive behavior. 23266708 2013
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.030 GeneticVariation phenotype BEFREE We evaluated associations between ADH1B/ALDH2 genotypes and the body weight and body mass index (BMI) of 1,301 Japanese alcoholic men at the time of their first visit to an addiction center. 23414439 2013
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.030 Biomarker phenotype BEFREE Determining the influences of genes involved in metabolizing dopamine and encoding dopamine receptors, such as the aldehyde dehydrogenase 2 (ALDH2) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) genes, is critical for understanding addictive behavior. 21723677 2012
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.010 GeneticVariation group BEFREE Regarding associations between histologic type and genotypes, the ALDH(2) variant allele was significantly less common in patients who had adenocarcinoma compared with controls. 17559142 2007
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.010 AlteredExpression disease BEFREE Overexpression of ALDH2 inhibited malignant features of lung adenocarcinoma cells, such as proliferation, stemness and migration, whereas ALDH2 knockdown increased these features. 31071657 2019
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 GeneticVariation group LHGDN Individuals with the variant alleles ALDH2*2 and MTHFR 677T had a decreased risk of colorectal adenomas, showing adjusted odds ratios of 0.70 (95% confidence interval 0.49-1.00) for all adenomas and 0.57 (0.34-0.95) for large adenomas (> or = 5 mm), as compared to individuals with ALDH2*1/1 and MTHFR 677CC genotypes combined. 16108833 2005
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 Biomarker group BEFREE Individuals with the variant alleles ALDH2*2 and MTHFR 677T had a decreased risk of colorectal adenomas, showing adjusted odds ratios of 0.70 (95% confidence interval 0.49-1.00) for all adenomas and 0.57 (0.34-0.95) for large adenomas (> or = 5 mm), as compared to individuals with ALDH2*1/1 and MTHFR 677CC genotypes combined. 16108833 2005
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.020 GeneticVariation disease BEFREE In addition, there were no clear interactions of the ADH1B with ALDH2 Glu487Lys and MTHFR C677T with regard to the risk of colorectal adenoma. 21517275 2011
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.020 GeneticVariation disease BEFREE Neither MTHFR C677T nor ALDH2 showed a measurable association with colorectal adenoma. 16108833 2005
CUI: C0162309
Disease: Adrenoleukodystrophy
Adrenoleukodystrophy 		0.030 GeneticVariation disease BEFREE ADH2 * 2 and ALDH2 X 2 may contribute to susceptibility for ALD. 12173598 2002
CUI: C0162309
Disease: Adrenoleukodystrophy
Adrenoleukodystrophy 		0.030 AlteredExpression disease BEFREE The present study aimed to investigate if MitoQ could preserve mitochondrial ALDH2 activity and speed up acetaldehyde clearance, thereby protects against ALD. 29156373 2018
CUI: C0162309
Disease: Adrenoleukodystrophy
Adrenoleukodystrophy 		0.030 Biomarker disease BEFREE ALDH2 genotyping was performed in 535 healthy controls and 281 patients with ALD. 29779728 2018