|
Adult Liver Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Surprisingly, we found that low ALDH2 expression levels associated with high XRCC1 expression levels are indicative for a poor overall survival, particularly in lung and liver cancer patients.
|
30088263 |
2018 |
|
Adult Liver Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles.
|
31279903 |
2019 |
|
Adult Liver Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Silencing transcription factor FOXM1 represses proliferation, migration, and invasion while inducing apoptosis of liver cancer stem cells by regulating the expression of ALDH2.
|
31580537 |
2020 |
|
Adult Liver Carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Recent evidence suggested that genetic polymorphism in ALDH2 gene may be significantly correlated with the susceptibility to cancer, such as colorectal cancer, esophageal cancer, and liver cancer.
|
26804999 |
2016 |
|
Agranulocytosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The ALDH2*1/*2 genotype was associated with leukocytopenia (<4,000/μl; adjusted odds ratio [95% confidence interval] = 1.89 [1.27 to 2.80]), granulocytopenia (<2,000/μl; 1.86 [1.22 to 2.82]), monocytopenia (<250/μl; 2.22 [1.49 to 3.29]), and lymphocytopenia (<1,000/μl; 1.93 [1.32 to 2.83]).
|
26917006 |
2016 |
|
Airway Obstruction
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This pilot study demonstrated for the first time a significant gene-environment interaction between the ALDH2*2 allele and cumulative exposure to cigarette smoke on the risk of airway obstruction.
|
25978981 |
2015 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals.
|
17454860 |
2007 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The high prevalence of the ALDH2*2 and ADH1B*2 alleles in a large percentage of Asian subgroups has been studied as a potential protective factors against alcohol abuse, yet some individuals who possess these genes still engage in problematic alcohol use (Wall et al.2001).
|
27159808 |
2016 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
A mutation in the gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2-2), present in some Asian populations, lowers or abolishes the activity of this enzyme and results in elevations in blood acetaldehyde upon ethanol consumption, a phenotype that greatly protects against alcohol abuse and alcoholism.
|
11535626 |
2001 |
|
Alcohol abuse
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Individuals who carry a low-activity ALDH2 (ALDH2*2) display high blood acetaldehyde levels after ethanol consumption, which leads to dysphoric effects, such as facial flushing, nausea, dizziness, and headache ("Asian alcohol phenotype"), which result in an aversion to alcohol and protection against alcohol abuse and alcoholism.
|
19251111 |
2009 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Acetaldehyde, polymorphisms and the cardiovascular system.
|
17590986 |
2007 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
BEFREE |
Drinking problems negatively correlated with positive alcohol flushing response and inactive ALDH2 (all p-values < 0.05).
|
29205834 |
2018 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In Asian populations the ALDH2-2 allele appears protective against alcohol abuse and alcoholism, but may favour alcoholic liver disease.
|
8974312 |
1994 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Individuals who carry a low-activity ALDH2 (ALDH2*2) display high blood acetaldehyde levels after ethanol consumption, which leads to dysphoric effects, such as facial flushing, nausea, dizziness, and headache ("Asian alcohol phenotype"), which result in an aversion to alcohol and protection against alcohol abuse and alcoholism.
|
19251111 |
2009 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although the ALDH2*2 allele had a significant inhibitory effect on alcohol consumption, hence on drinking problems, the apparent association was not confirmed between ADH2 genotype and overall drinking patterns for either males or females.
|
8727242 |
1996 |
|
Alcohol abuse
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A mutation in the gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2-2), present in some Asian populations, lowers or abolishes the activity of this enzyme and results in elevations in blood acetaldehyde upon ethanol consumption, a phenotype that greatly protects against alcohol abuse and alcoholism.
|
11535626 |
2001 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
CTD_human |
Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action.
|
16404797 |
2005 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Relevance of both daily hassles and the ALDH2 genotype to problem drinking among Japanese male workers.
|
9514293 |
1998 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ALDH2 genotypes consistently and strongly affected the alcohol sensitivity, drinking behavior and problem drinking in both the younger and older group.
|
26825972 |
2016 |
|
Alcohol abuse
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The ALDH2*2 allele, detected in nearly half of the subjects, showed an overwhelming protective effect against a high level of alcohol consumption and problem drinking behavior, as determined by the Kurihama Alcoholism Screening Test (KAST).
|
12211622 |
2002 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, persons with the heterozygous ALDH2*2 genotype (ALDH2*1/2*2) are at higher risk for developing alcohol abuse-related end-organ damage than those with a homozygous ALDH2*1/2*1 genotype.
|
9211568 |
1997 |
|
Alcohol abuse
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ALDH2*2 allele, detected in nearly half of the subjects, showed an overwhelming protective effect against a high level of alcohol consumption and problem drinking behavior, as determined by the Kurihama Alcoholism Screening Test (KAST).
|
12211622 |
2002 |
|
Alcohol abuse or dependence
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the Han Chinese population, the alcohol dehydrogenase 1B*2/*2 (ADH1B*2/*2) genotype and the aldehyde dehydrogenase 2*2 (ALDH2*2) allele have been considered as protective factors against alcohol abuse or dependence.
|
15084894 |
2004 |
|
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
"ALDH2 is associated to alcohol dependence and is the major genetic determinant of ""daily maximum drinks"" in a GWAS study of an isolated rural Chinese sample."
|
24277619 |
2014 |