|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A review of case-control studies of the effects of ALDH2, ADH2 and ADH3 genotypes shows consistently positive associations between inactive heterozygous ALDH2 and the less-active ADH2 genotypes and the risk for esophageal cancer in East Asian heavy drinkers and this enzyme-related vulnerability may extend to light-to-moderate drinkers.
|
12672787 |
2003 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After adjustment for age, daily alcohol consumption and amount of cigarette smoking, significantly increased risks (odds ratios) in the presence of the ALDH2 *2 allele were found for oropharyngolaryngeal (11.14), esophageal (12.50), stomach (3.49), colon (3.35), lung (8.20) and esophageal cancer concomitant with oropharyngolaryngeal and/or stomach cancer (54.20) but not for liver or other cancers.
|
9744533 |
1998 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Inactive ALDH2 encoded by ALDH2*1/2*2 and the low-activity form of alcohol dehydrogenase (ADH)-2 encoded by ADH2*1/2*1 enhance the risk for esophageal cancer in Japanese light to heavy drinkers, a significant association that emphasizes the importance of screening tests for inactive ALDH2 based on alcohol flushing.
|
14652286 |
2003 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inactive heterozygous aldehyde dehydrogenase-2 (ALDH2(*)1/(*)2) and less-active alcohol dehydrogenase-1B (ADH1B(*)1/(*)1) increase the risk of esophageal cancer in East Asian drinkers, and esophageal cancer multiplicity is strongly associated with ALDH2(*)1/(*)2. p53 alterations are key molecular events in multifocal carcinogenesis in the esophagus.
|
21601984 |
2011 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China.
|
21157980 |
2010 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that to help lower their risk for esophageal cancer, persons with the ALDH2*2 allele should be encouraged to reduce their consumption of alcoholic beverages.
|
8850269 |
1996 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
For individuals with both ALDH2*1/2*2 and ADH2*1/2*1, the risk of esophageal cancer was enhanced in a multiplicative fashion (OR = 30.12), whereas for those with either ALDH2*1/2*2 or ADH2*1/2*1 alone the ORs were 7.36 and 4.11.
|
12419833 |
2002 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have carried out a meta-analysis of studies looking at the ALDH2 genotype and esophageal cancer and found that risk was reduced among *2*2 homozygotes [odds ratio (OR), 0.36; 95% confidence interval (95% CI), 0.16-0.80] and increased among heterozygotes (OR, 3.19; 95% CI, 1.86-5.47) relative to *1*1 homozygotes.
|
16103445 |
2005 |
|
Malignant neoplasm of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In this study, we further investigated the expression of ALDH2 in esophagus and its relationship with risk factors of esophageal cancer.
|
15970497 |
2005 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thus polymorphisms of alcohol-metabolizing enzymes, that is, ADH2 and ALDH2, may be useful for screening patients at high risk for esophageal cancer, which might facilitate clarification of esophageal tumorigenesis and prevention of esophageal cancer.
|
9451664 |
1997 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism in the ALDH2 gene plays a central role in Asian alcohol hypersensitivity and has been associated with the risk for esophageal cancer.
|
10737710 |
2000 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADH2 and ALDH2 genotypes are associated with esophageal cancer risk.
|
17963305 |
2007 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Because of the high prevalence of ALDH2*2 allele among East Asian populations, East Asians may be more susceptible to the carcinogenic effect of alcohol, with most evidence coming from studies of esophageal cancer and head and neck cancer, while data for other cancers are more limited.
|
28253921 |
2017 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, we determined the polymorphism of CD14 gene and aldehyde dehydrogenase gene 2 (ALDH 2) in 335 alcoholic patients with different organ complications i.e., cirrhosis of liver (n = 100), acute pancreatitis (n = 100), esophageal cancer (n = 82) and avascular necrosis of hip joint (AVN) (n = 53) and 194 non-alcoholic controls in a Chinese group.
|
16273622 |
2005 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results demonstrated the difference in the frequency of ALDH2 heterozygote between the patients with esophageal cancer and patients with head and neck cancer.
|
10235272 |
1999 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ALDH2-deficient individuals have a dramatically elevated risk of esophageal cancer from alcohol consumption.
|
24588059 |
2014 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, the results remain inconclusive.We conducted a comprehensive meta-analysis including 63 articles with 66 studies containing 25,682 cases and 47,455 controls retrieved by searching PubMed and Embase electronic databases up to March 5, 2018.Pooled results indicated that ALDH2 gene rs671 polymorphism was significantly associated with the overall cancer risk in Asians (homozygous model: odds ratio [OR] = 0.85, 95% confidence interval [CI] = 0.72-0.99, P = .042; heterozygous model: OR = 1.32, 95% CI = 1.14-1.52, P < .001; recessive model: OR = 0.73, 95% CI = 0.60-0.88, P = .001; dominant model: OR = 1.32, 95% CI = 1.16-1.51, P < .001; and allele comparison model: OR = 1.11, 95% CI = 1.03-1.19, P = .004), especially in esophageal cancer and among the Chinese and the Japanese.Our results suggest that ALDH2 rs671 polymorphism is associated with the overall cancer risk in Asians.
|
30921184 |
2019 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
|
19698717 |
2009 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
In conclusion, low-activity ALDH2 was associated with increased EC risk among male heavy alcohol consumers.
|
29707772 |
2018 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our finding showed that ALDH2*1/*2 genotype increases the risk of esophageal cancer, while the ALDH2*2/*2 genotype reduces the risk, presumably preventing people from consumption due to discomfort.
|
22320964 |
2011 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among carriers who drank alcohol at least thrice to four times a week, the AF(c) for having at least one ALDH2 variant was 49% (21.3-66.8%) for all upper aerodigestive tract cancers, increasing to 68.9% (42.9-83.1%) for esophageal cancer.
|
16614111 |
2006 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It further confirmed that ALDH2 Glu487Lys polymorphism was a high-risk factor for esophageal cancer.
|
28422823 |
2017 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
While the distributions of esophageal cancer and ALDH2*504Lys do not precisely correlate, that does not disprove the hypothesis.
|
19456322 |
2009 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The association of lifestyle habits and polymorphism of ADH2 and ALDH2 genes with the risk of esophageal cancer in Thai population was investigated in a hospital-based case-control study: 202 cases and 261 controls.
|
12213289 |
2002 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Its encoding gene ALDH2 has a functional polymorphism: ALDH2 Glu487LYS: An association between this polymorphism and esophageal cancer among alcoholics has been reported.
|
11375898 |
2001 |