|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
A strong association between inactive aldehyde dehydrogenase-2 (ALDH2) and risk of esophageal cancer has been demonstrated in East Asian drinkers.
|
22458712 |
2013 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
The risk of esophageal cancer was markedly higher in heavy drinkers with ALDH2*1/*2 than in never/rare drinkers with ALDH2*1/*1 [adjusted OR (95% CI) = 59.1 (4.65-750)].
|
16499490 |
2006 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
The acetaldehyde increase due to ALDH2 inactivity was calculated to be 6.7 μg/kg bw/day for heavy drinkers, which is associated with odds ratios of up to 7 for head and neck as well as oesophageal cancer.
|
28257851 |
2017 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Because moderate and heavy drinkers with ALDH2*1/2*2 have very high risks for esophageal cancer, MCV might serve as an indicator of these high-risk drinkers.
|
14506399 |
2003 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
In alcohol drinkers, ALDH2-deficiency is a well-known risk factor for upper aerodigestive tract cancers, i.e., head and neck cancer and esophageal cancer.
|
25831092 |
2015 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The low activity ALDH2*2 allele was significantly associated with increased risk for oesophageal cancer amongst the Black subjects (odds ratio, 2.35; p=0.0084).
|
18254707 |
2008 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
There were significant correlations between ALDH2 genotypes and alcohol drinking/smoking/history of esophageal cancer.
|
20632450 |
2010 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the mutant ALDH2*2 allele were significantly higher in patients with esophageal cancer (27.7%) than in healthy control subjects (7.3%; p< 0.0001; habitual alcohol drinkers).
|
12198369 |
2002 |
|
Malignant neoplasm of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Deficiencies in mitochondrial low-Km aldehyde dehydrogenase (ALDH2) activity, and consequently high blood acetaldehyde levels, have been suggested to relate to various diseases in Japanese, including esophageal cancer.
|
16365683 |
2006 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ALDH2, MTHFR C677T, CYP1A1 Ile/Val, CYP1A1MspI, CYP2E1, GSTP1, GSTM1 and GSTT1 were examined by meta-analyses and significant relations were found between ALDH2*1*2 and the CYP1A1 Val allele and increased risk of esophageal cancer.
|
17674367 |
2007 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Kaplan-Meier estimates of the proportions of patients with additional primary esophageal cancers showed that patients with inactive ALDH2 (P = 0.024) or multiple esophageal cancers (P = 0.007) had a significantly increased likelihood of the development of additional cancer.
|
9641490 |
1998 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that polymorphisms of ADH2 and ALDH2 can modify the influence of alcoholic consumption on esophageal cancer risk.
|
16127737 |
2005 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Statistical interaction between ALDH2 (rs671) and alcohol drinking on EC susceptibility in both additive and multiplicative scales was observed.
|
22930414 |
2013 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The triple combination of the risk factors of the inactive ALDH2, stronger alcoholic beverages and heavy smoking was more commonly associated with multiple-cancer patients than with patients with esophageal cancer alone (62.5% vs. 7.1%).
|
8903472 |
1996 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the examination of genotypes of ALDH2 loci and HLA haplotypes may allow the early detection of esophageal cancer in the Japanese population.
|
12168074 |
2003 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The key findings of the earlier studies were that variations (i.e., polymorphisms) in the DNA sequences of the genes encoding alcohol dehydrogenase 1B (i.e., the ADH1B gene), aldehyde dehydrogenase 2 (i.e., the ALDH2 gene), and other alcohol-metabolizing enzymes mediate the risk for alcoholism; moreover, these polymorphisms also have an impact on the risk of alcohol-related cancers, such as esophageal cancer.
|
23134043 |
2012 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for age, drinking and smoking habits, BMI and ALDH2/ADH2 genotypes, macrocytosis of MCV > or =106 fl was associated with increased risk for esophageal cancer (OR = 2.75).
|
12949054 |
2003 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADH1B/ALDH2 genotypes affect the risk of esophageal cancer, and the risk is modified by alcohol consumption, ethnicity, and gender.
|
20806441 |
2010 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Compared with individuals carrying both ALDH2 G/G and ADH2 A/A alleles and with a cumulative amount of alcohol consumption <2.5 (kg * years), drinkers carrying both ALDH2 A and ADH2 G alleles and with a cumulative amount of alcohol consumption > or =2.5 (kg * years) showed a significantly elevated risk of esophageal cancer (OR=53.15, 95% CI: 4.24-666.84).
|
20010786 |
2010 |
|
Malignant neoplasm of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Persons with inactive ALDH2 may have a higher risk of alcohol-related oral, pharyngeal and esophageal cancers, compared with those with wild-type ALDH2.
|
29136221 |
2017 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine the effects of ALDH2 and ADH2 genotypes in genetically based cancer susceptibility, lymphocyte DNA samples from 668 Japanese alcoholic men more than 40 years of age (91 with and 577 without esophageal cancer) were genotyped and the results were expressed as odds ratios (ORs).
|
10591585 |
1999 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.
|
25680115 |
2015 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study aims to investigate the relationship between ALDH2 rs671 and c12orf30 rs4767364 polymorphisms in the chromosome 12q24 gene, and risk and prognosis of individuals developing esophageal cancer (ESCC) in Xinjiang Kazak and Han populations.
|
28464297 |
2018 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the present study revealed a significant gene-environment interaction between alcohol drinking and the ALDH2 polymorphism regarding esophageal cancer risk among a general population in Japan, providing concrete evidence of a role for acetaldehyde in neoplastic development.
|
16235983 |
2005 |
|
Malignant neoplasm of esophagus
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ALDH2*2 heterozygotes have a 7 to 12-fold increased risk for esophageal cancer, a risk increased by drinking alcohol and smoking.
|
31801381 |
2020 |