FANCA, FA complementation group A, 2175

N. diseases: 211; N. variants: 206
Disease: Prediabetes syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0362046
Disease: Prediabetes syndrome
Prediabetes syndrome 		0.010 Biomarker disease BEFREE Considering FAs not as mere amplifiers of glucose-stimulated insulin secretion (GSIS), but as parallel insulin granule exocytosis inductors, partly independent of the K<sub>ATP</sub> channel closure, we describe the FA initiating roles in the prediabetic state that is induced by retardations in the glycerol-3-phosphate (glucose)-promoted glycerol/FA cycle and by the impaired GPR40/FFA1 (free FA1) receptor pathway, specifically in its amplification by the redox-activated mitochondrial phospholipase, iPLA2γ. 29921789 2018