FANCG, FA complementation group G, 2189

N. diseases: 132; N. variants: 19
Disease: Pancreatic carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.060 GeneticVariation disease BEFREE Two truncating FANCC mutations but no truncating FANCG mutations were identified in young onset (<55 years) pancreatic cancer cases with no family history of pancreatic cancer. 15695377 2005
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.060 GeneticVariation disease BEFREE BRCA2, FANCC, and FANCG gene mutations are present in a subset of pancreatic cancer. 16243825 2005
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.060 Biomarker disease BEFREE Recently, several sequence changes in FANCC and FANCG were reported in pancreatic cancer. 15277238 2004
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.060 GeneticVariation disease BEFREE Since carriers of germline BRCA2 gene mutations have an increased risk of developing pancreatic cancer, the FA pathway has been investigated as a tumor suppressor pathway in pancreatic cancer.Recently van der Heijden et al. identified FANCC and FANCG gene mutations in patients with young-onset pancreatic cancer. 14726700 2004
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.060 GeneticVariation disease BEFREE The Fanconi genes BRCA2, FANCC and FANCG are mutated in a subset of pancreatic cancer. 15107617 2004
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.060 GeneticVariation disease BEFREE Here we report inherited and somatic mutations of FANCC and FANCG present in young-onset pancreatic cancer. 12750283 2003