FASN, fatty acid synthase, 2194

N. diseases: 245; N. variants: 6
Disease: liposarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023827
Disease: liposarcoma
liposarcoma 		0.320 Therapeutic disease CTD_human The FASN inhibitors cerulenin and orlistat reduced the growth of two LS cell lines (LiSa2, SW872), as did inhibition of ACC with soraphen A. CDDO-Me, a synthetic triterpenoid, suppressed expression of Spot 14 and FASN genes and likewise inhibited LS cell growth. 20372807 2010
CUI: C0023827
Disease: liposarcoma
liposarcoma 		0.320 AlteredExpression disease BEFREE CLA likewise suppressed levels of S14 and FAS mRNAs in liposarcoma cells and caused growth inhibition that was prevented by palmitic acid. 19116881 2009
CUI: C0023827
Disease: liposarcoma
liposarcoma 		0.320 AlteredExpression disease BEFREE Fatty acid synthase (FAS) is a key enzyme of de-novo fatty acid synthesis and is highly expressed in both human liposarcoma tissue specimens and LiSa-2 cells. 18259941 2008