FASN, fatty acid synthase, 2194

N. diseases: 245; N. variants: 6
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease BEFREE This immunohistochemical study aims to compare the utility of FASN and ACC in differentiating sentinel lymph nodes with metastatic melanomas from those with benign nodal nevi in patients with cutaneous melanoma. 28654463 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease BEFREE Our group has previously shown that the inhibition of FASN with orlistat reduces spontaneous lymphatic metastasis in experimental B16-F10 melanomas, which is a consequence, at least in part, of the reduction of proliferation and induction of apoptosis. 27918556 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.340 AlteredExpression disease BEFREE One such cancer is cutaneous melanoma, in which the level of FASN expression is associated with tumor invasion and poor prognosis. 24964211 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease CTD_human Taken together, these findings demonstrate the mitochondrial involvement in FASN inhibition-induced apoptosis in melanoma cells. 20805790 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease CTD_human Recently, we have demonstrated the mitochondrial involvement in FASN inhibition-induced apoptosis in melanoma cells. 21213365 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease CTD_human The chemical inhibition of FASN activity could have a potential benefit in association with the current chemotherapy for melanoma. 18770866 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease BEFREE The growth-inhibitory effects of FAS inhibitors cerulenin and C75 were then investigated on these cancer cell lines, particularly the human melanoma A-375. 17904792 2007