|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this report, we demonstrate that high fat diet induced obesity increases the severity of hyperoxic acute lung injury in mice in part by altering fatty acid synthase (FASN) levels in the lung.
|
31287803 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
A novel series of fatty acid synthase (FAS) inhibitors with D-(-)-pantolactone moiety and potential utility for the treatment of obesity were designed, synthesized and characterized, in which the structure of compound 3k was further confirmed by single X-ray diffraction.
|
31492533 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Collectively, our data suggest that FASN inhibitor AEC is a potential therapeutic agent for obesity.
|
28726934 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tetrahydrolipstatin (orlistat), an inhibitor of lipases and fatty acid synthase, is used orally for long-term treatment of obesity.
|
26035182 |
2015 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Obesity in WT mice fed a HFD associated with elevated serum IL-6 levels, fatty liver, upregulation of carnitine palmitoyltransferase 1 (CPT1) and signal transducer and activator of transcription-3 (STAT3), increased AMP kinase phosphorylation (p-AMPK), and downregulation of the hepatic lipogenic enzymes fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1).
|
26035386 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
CP and OS infusions suppressed hepatic tissue fat accumulation, and significantly down-regulated the mRNA levels of two hepatic lipogenesis genes: sterol regulatory element binding protein 1c (SREBP1c) and fatty acid synthase (FAS) compared with the obese control.
|
24584283 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fatty acid synthase (FASN) is a potential therapeutic target for treatment of cancer and obesity, and is highly elevated in 30% of HER2-overexpressing breast cancers.
|
22767439 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Unexpectedly, the lipogenic enzyme fatty acid synthase (FAS) was increased in the skeletal muscle of mice with diet-induced obesity and insulin resistance.
|
23376793 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide interrogation by BMI suggested differences in gene expression of metabolic and fatty acid genes, including fatty acid synthase (FASN), consistent with the obesity paradox.
|
24285872 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Orchestrated downregulation of genes involved in oxidative metabolic pathways in obese vs. lean high-fat young male consumers.
|
20882379 |
2011 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In a representative subgroup of nonobese (n = 4) and obese women (n = 6), relative FAS gene expression levels significantly correlated (r = 0.657, P = 0.034; n = 10) with FAS protein values.
|
19543203 |
2010 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Significant interactions of BMI with FASN polymorphisms and FASN tumor expression suggest FASN as a potential link between obesity and poor PCa outcome and raise the possibility that FASN inhibition could reduce PCa-specific mortality, particularly in overweight men.
|
20679621 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data indicate a role of FASN genetic variation in susceptibility to obesity in adults.
|
19876008 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Val1483Ile in FASN gene is linked to central obesity and insulin sensitivity in adult white men.
|
19300427 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The human FAS gene (FAS) maps to chromosome 17q25, a region previously shown to have suggestive linkage to adiposity in a genome-wide linkage scan for genetic determinants of obesity in Pima Indians.
|
15220220 |
2004 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Fatty acid synthase (FAS) activity is a potential therapeutic target to treat cancer and obesity.
|
15235125 |
2004 |