FASN, fatty acid synthase, 2194

N. diseases: 245; N. variants: 6
Disease: ovarian neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.390 Biomarker disease BEFREE Dendritic cells educated by FASN<sup>high</sup> OvCa ascites are defective in their ability to present antigens and prime T cells. 30619288 2018
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.390 Biomarker disease BEFREE In our study, we investigated whether FASN inhibition using orlistat is an effective adjunctive treatment for ovarian cancers that have become platinum resistant using a cisplatin-resistant ovarian tumour xenograft model in mice. 29569717 2018
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.390 AlteredExpression disease BEFREE Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer. 25947066 2015
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.390 Biomarker disease BEFREE Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells. 25302649 2015
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.390 Biomarker disease BEFREE These findings suggest that FASN plays a critical role in the peritoneal metastasis of ovarian cancer. 24979135 2014
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.390 Biomarker disease CTD_human Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis. 21442130 2011
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.390 Biomarker disease BEFREE Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer. 21970855 2011
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.390 Biomarker disease BEFREE The study suggests that molecular targeting of FAS and FAK by HO-3867 may be a potential strategy for ovarian cancer therapy. 20713491 2010
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.390 AlteredExpression disease BEFREE Activation of AKT and overexpression of fatty acid synthase (FAS) are frequently observed in human ovarian cancer. 15806173 2005
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.390 AlteredExpression disease BEFREE Overexpression of fatty acid synthase (FAS) in certain breast, prostate and ovarian tumors has been correlated with aggressive cancer phenotype and poor prognosis. 10737707 2000