FASN, fatty acid synthase, 2194

N. diseases: 245; N. variants: 6
Disease: HER2 gene amplification ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1512127
Disease: HER2 gene amplification
HER2 gene amplification 		0.020 AlteredExpression disease BEFREE In vitro studies revealed that BC cells bearing HER2 gene-amplification released higher levels of extracellular FASN than HER2-negative BC cells. 19885560 2009
CUI: C1512127
Disease: HER2 gene amplification
HER2 gene amplification 		0.020 AlteredExpression disease BEFREE We previously reported that pharmacological and RNA interference-induced inhibition of tumor-associated fatty acid synthase (FASN; Oncogenic antigen-519), a key metabolic enzyme catalyzing the synthesis of long-chain saturated fatty acids, drastically down-regulates HER2 expression in human breast cancer cells bearing HER2 gene amplification. 17786307 2007