Moreover, we observed that vaccinating mice with heat-killed <i>fbp1</i>Δ induces significant cross-protection against challenge with diverse invasive fungal pathogens, including <i>C. neoformans</i>, <i>C. gattii</i>, and <i>Aspergillus fumigatus</i>, as well as partial protection against <i>Candida albicans</i> Thus, our data suggest that the heat-killed <i>fbp1Δ</i> strain has the potential to be a suitable vaccine candidate against cryptococcosis and other invasive fungal infections in both immunocompetent and immunocompromised populations.<b>IMPORTANCE</b> Invasive fungal infections kill more than 1.5 million people each year, with limited treatment options.