|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
ALKBH3 can promote cancer cell proliferation, migration and invasion.
|
30541109 |
2019 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Overexpression of ALKBH3 increases CSF-1 expression and the degree of cancer cell invasiveness without affecting cell proliferation or migration.
|
30342176 |
2019 |
|
Primary malignant neoplasm
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Overexpression of ALKBH3 increases CSF-1 expression and the degree of cancer cell invasiveness without affecting cell proliferation or migration.
|
30342176 |
2019 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
ALKBH3 can promote cancer cell proliferation, migration and invasion.
|
30541109 |
2019 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Because of its role in promoting tumor cell proliferation and metastasis of cancer, extensive efforts are being directed in developing selective inhibitors for AlkBH3.
|
30041948 |
2018 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
Because of its role in promoting tumor cell proliferation and metastasis of cancer, extensive efforts are being directed in developing selective inhibitors for AlkBH3.
|
30041948 |
2018 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
However, it is currently unknown whether ALKBH2 or ALKBH3 are found inactivated in cancer.
|
28679371 |
2017 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
However, it is currently unknown whether ALKBH2 or ALKBH3 are found inactivated in cancer.
|
28679371 |
2017 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
The PCA-1/ALKBH3 gene implicated in DNA repair is expressed in several human malignancies but its precise contributions to cancer remain mainly unknown.
|
22826605 |
2012 |
|
Primary malignant neoplasm
|
0.080 |
AlteredExpression
|
group |
BEFREE |
The PCA-1/ALKBH3 gene implicated in DNA repair is expressed in several human malignancies but its precise contributions to cancer remain mainly unknown.
|
22826605 |
2012 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
|
22055184 |
2011 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
We suggest that ALKBH3 contributes significantly to cancer cell survival and may be a therapeutic target for human adenocarcinoma of the lung.
|
21285982 |
2011 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
We suggest that ALKBH3 contributes significantly to cancer cell survival and may be a therapeutic target for human adenocarcinoma of the lung.
|
21285982 |
2011 |
|
Primary malignant neoplasm
|
0.080 |
Biomarker
|
group |
BEFREE |
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
|
22055184 |
2011 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Interestingly, long-term culture using androgen-free medium increased the level of PCA-1 and the related expression of Bcl-xl and DDR-1 in the androgen-sensitive cancer cell line LNCaP, suggesting that PCA-1 signaling is associated with androgen independence.
|
17970783 |
2008 |
|
Primary malignant neoplasm
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Interestingly, long-term culture using androgen-free medium increased the level of PCA-1 and the related expression of Bcl-xl and DDR-1 in the androgen-sensitive cancer cell line LNCaP, suggesting that PCA-1 signaling is associated with androgen independence.
|
17970783 |
2008 |
|
Malignant neoplasm of prostate
|
0.050 |
Biomarker
|
disease |
BEFREE |
Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker.
|
26967262 |
2016 |
|
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker.
|
26967262 |
2016 |
|
Malignant neoplasm of prostate
|
0.050 |
Biomarker
|
disease |
BEFREE |
Here, we show that ALKBH3 gene silencing markedly induces apoptosis in hormone-independent prostate cancer cell line DU145 but not in the normal prostate epithelial cell line PNT2.
|
22515525 |
2012 |
|
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Here, we show that ALKBH3 gene silencing markedly induces apoptosis in hormone-independent prostate cancer cell line DU145 but not in the normal prostate epithelial cell line PNT2.
|
22515525 |
2012 |
|
Malignant neoplasm of prostate
|
0.050 |
Biomarker
|
disease |
BEFREE |
We have demonstrated for the first time that a novel human AlkB homologue, ALKBH3, contributes to prostate cancer development, but its clinical and biological roles in lung cancer remain unclear.
|
21285982 |
2011 |
|
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
We have demonstrated for the first time that a novel human AlkB homologue, ALKBH3, contributes to prostate cancer development, but its clinical and biological roles in lung cancer remain unclear.
|
21285982 |
2011 |
|
Malignant neoplasm of prostate
|
0.050 |
Biomarker
|
disease |
BEFREE |
Taken together, we propose that PCA-1-DDR-1 signaling is a new important axis involved in malignant potential prostate cancer associated with hormone-refractory status.
|
17970783 |
2008 |
|
Prostate carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Taken together, we propose that PCA-1-DDR-1 signaling is a new important axis involved in malignant potential prostate cancer associated with hormone-refractory status.
|
17970783 |
2008 |