FCGR3B, Fc fragment of IgG receptor IIIb, 2215

N. diseases: 291; N. variants: 8
Disease: Septicemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036690
Disease: Septicemia
Septicemia 		0.030 AlteredExpression disease BEFREE While neutrophil CD16 did not discriminate for sepsis, decreased expression was associated with increased mortality risk. 31584643 2019
CUI: C0036690
Disease: Septicemia
Septicemia 		0.030 AlteredExpression disease BEFREE These observations are strengthened by our finding that patients with sepsis, a disease involving elevated Wnt5a and IL-6 levels, also showed a significant increase in the CD14⁺ CD16⁺⁺/CD14⁺/⁺⁺ CD16⁺ monocyte populations, which was accompanied by a significant decrease in circulating mDCs. 23679576 2013
CUI: C0036690
Disease: Septicemia
Septicemia 		0.030 Biomarker disease BEFREE Collectively, the results from the current study demonstrate CD16 as a key regulator of the TRIF-dependent TLR4 pathway in human monocytes and their CD16-expressing subset, with implications in sepsis. 22427642 2012