In two patients, cancer was detected at the time of renal biopsy (small-cell carcinoma of the lung and prostatic adenocarcinoma with neuroendocrine differentiation).Both tumours were negative forTHSD7A.
In order to better define the underlying immunologic processes, we systematically analyzed circulating antigen-specific IgG subclasses in the serum of 76 patients with PLA<sub>2</sub>R1-associated MN and 41 patients with THSD7A-associated MN in relationship to concurrent malignancy and disease outcome.
Patients with THSD7A-associated MN differ in their clinical characteristics from patients with PLA<sub>2</sub>R1-associated MN, and more intensive screening for the presence of malignancies may be warranted in those with THSD7A-associated MN.