|
Malignant neoplasm of lung
|
0.490 |
Biomarker
|
disease |
BEFREE |
The combination of an AKT inhibitor and cisplatin efficiently suppressed lung cancer cell growth both <i>in vitro</i> and <i>in vivo</i> Our study illustrated an upstream regulatory mechanism of FEN1, which will contribute to the development of effective lung cancer therapies.These findings identified AKT as a regulator of FEN1 activity and revealed the AKT signaling pathway's contribution to drug resistance, which will contribute to the development of effective lung cancer therapy.
|
31467180 |
2019 |
|
Malignant neoplasm of lung
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
This study indicates that although FEN1 polymorphisms, c.-69G>A (rs174538) and c.4150G>T (rs4246215) are not genetically associated with FECD, its transcript regulation reported in other diseases such as lung cancer which are genetically associated by rs4246215 could be mediated through miRNA, hsa-miR-1236-3p.
|
30260965 |
2018 |
|
Malignant neoplasm of lung
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Here we report that triptolide reduced lung cancer incidence from 70% to 10% in a Fen1 E160D transgenic mouse model and effectively inhibited cancer growth and metastasis in A549 and H460 mouse xenografts.
|
30006924 |
2018 |
|
Malignant neoplasm of lung
|
0.490 |
Biomarker
|
disease |
BEFREE |
Manipulating the amount of FEN1 altered the response of lung cancer cells to chemotherapeutic drugs.
|
28371273 |
2017 |
|
Malignant neoplasm of lung
|
0.490 |
Biomarker
|
disease |
CTD_human |
The FEN1 inhibitor significantly suppressed cell proliferation and induced DNA damage in lung cancer cells.
|
28371273 |
2017 |
|
Malignant neoplasm of lung
|
0.490 |
AlteredExpression
|
disease |
BEFREE |
Elevated Fen1 levels in breast and lung cancer cells may reflect the enhanced proliferation of cancer cells or increased DNA damage in cancer cells compared to normal cells.
|
27088617 |
2016 |
|
Malignant neoplasm of lung
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
There are two functional genetic variants (-69G>A and 4150G>T) in the FEN1 gene, which have been associated with DNA damage levels in coke-oven workers as well as risks of lung cancer, hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer in general populations.
|
23184144 |
2013 |
|
Malignant neoplasm of lung
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Two functional germ line variants (-69G > A and 4150G > T) in the FEN1 gene have been associated with DNA damage levels in coke oven workers and lung cancer risk in general populations.
|
22072618 |
2012 |
|
Malignant neoplasm of lung
|
0.490 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese.
|
21725308 |
2011 |
|
Malignant neoplasm of lung
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
These results highlight FEN1 as an important gene in human carcinogenesis and genetic polymorphisms in FEN1 confer susceptibility to lung cancer.
|
19618370 |
2009 |
|
Malignant neoplasm of lung
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that alterations of FEN1 are not likely to contribute to development of lung cancer.
|
14562054 |
2003 |
|
Colorectal Carcinoma
|
0.430 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
|
31089142 |
2019 |
|
Colorectal Carcinoma
|
0.430 |
Biomarker
|
disease |
BEFREE |
It is also thought that the product of the APC gene can modulate base excision repair (BER) pathway through an interaction with DNA polymerase β (Pol-β) and flap endonuclease 1 (Fen-1) to mediate CRC cell apoptosis.
|
26334567 |
2015 |
|
Colorectal Carcinoma
|
0.430 |
GeneticVariation
|
disease |
GWASDB |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
Colorectal Carcinoma
|
0.430 |
Biomarker
|
disease |
CTD_human |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
Colorectal Carcinoma
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
There are two functional genetic variants (-69G>A and 4150G>T) in the FEN1 gene, which have been associated with DNA damage levels in coke-oven workers as well as risks of lung cancer, hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer in general populations.
|
23184144 |
2013 |
|
Colorectal Carcinoma
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
Functional FEN1 genetic variants contribute to risk of hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer.
|
22072618 |
2012 |
|
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
|
31089142 |
2019 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
Lung Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer.
|
28371273 |
2017 |
|
Lung Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
Our data show a clear overexpression of FEN1 in 19/25 samples from testicular tumors (mostly seminomas) and 4/4 samples from lung tumors (non-small cell lung cancer).
|
19596913 |
2009 |
|
Lung Neoplasms
|
0.320 |
GeneticVariation
|
group |
LHGDN |
Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer.
|
14562054 |
2003 |
|
Malignant tumor of colon
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
|
31089142 |
2019 |
|
Malignant tumor of colon
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
The compound JFD00950 was identified as a novel FEN1 inhibitor with in vitro inhibition of flap cleavage activity as well as cytotoxic activity against a colon cancer cell line, DLD-1.
|
28685785 |
2017 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that miR-140 acts as a tumor suppressor in breast cancer by inhibiting FEN1 to repress DNA damage repair and reveal miR-140 to be a new anti-tumorigenesis factor for adjunctive breast cancer therapy.
|
31471584 |
2020 |