|
Acute Cerebrovascular Accidents
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We suggest that up-regulation of FGF-2 is one of the mechanisms that leads to angiogenesis and neuro-protection in the penumbra region after acute stroke in man.
|
16132618 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
APL expressed high levels of FGF13 and FGFR1 as well as two potent angiogenic factors, HGF and VEGF.
|
15674361 |
2005 |
|
Addictive Behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Notably, stepwise neoplastic transformation is accompanied by a gradual increase in FGF13 expression and increased dependence on FGF13 for survival ("nononcogene addiction").
|
27994142 |
2017 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Although we found a trend towards reduced disease-free survival in patients with FGF-2 overexpressing esophageal adenocarcinomas, significantly worse disease-free survival was noted among patients whose tumors did not also overexpress the FGF-AS b isoform (p = 0.03).
|
17569023 |
2007 |
|
Adenocarcinoma Of Esophagus
|
0.030 |
Biomarker
|
disease |
BEFREE |
We previously reported that elevated FGF-AS expression is associated with reduced tumor recurrence and improved survival rates in patients with FGF-2-dependent esophageal adenocarcinoma.
|
20945415 |
2010 |
|
Adenocarcinoma Of Esophagus
|
0.030 |
Biomarker
|
disease |
BEFREE |
In contrast, both the overall percentage of FGF-2-reactive OAs and the overall FGF-2 protein expression, assessed using an immunoreactivity score, are comparable to FGF-2 expression in controls.
|
10383711 |
1999 |
|
Adenocarcinoma Of Esophagus
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our data implicate the FGF-AS b isoform in modulation of FGF-2 expression and clinical outcome in esophageal adenocarcinoma.
|
17569023 |
2007 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
While normal pituitary expresses GFG but not FGF-2, pituitary adenomas express FGF-2 and have reduced levels of GFG; aggressive and recurrent adenomas expressed more FGF than GFG mRNA.
|
11266510 |
2001 |
|
Adenoma
|
0.020 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry of the excised tumor revealed strong immunoreactivity for VEGF and FGF-2, two potent angiogenic factors, and CD31 (an endothelial marker) indicating high vascularization of the adenoma.
|
19172414 |
2009 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells.
|
8883950 |
1996 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining and the RNA-seq (sequencing) data from the IVY Glioblastoma Atlas Project showed FGF13 expression in glioma cells in the invasive edges of tumor specimens.
|
29059154 |
2018 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that total sulfated GAGs from hippocampus of Alzheimer's disease have altered capacities to bind and potentiate the activities of growth factors including FGF-2, VEGF, and BDNF while their capacity to bind to tau is remarkable increased.
|
30608949 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Characterizing the multiple roles of FGF-2 in SOD1<sup>G93A</sup> ALS mice in vivo and in vitro.
|
30370540 |
2019 |
|
Anaplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The levels of FGF-1 mRNA and FGF-2 and its mRNA tended to increase with dedifferentiation (especially grade G3), myometrial invasion (especially grade C) and staging (especially stages III and IV) in endometrial cancers were significantly (p < 0.05) higher than those in normal endometria.
|
8685603 |
1996 |
|
Anaplasia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
FGF-2 and laminin 5 expression were found throughout benign and atypical dedifferentiation in mammary tissue samples and were lost primarily with transformation to invasive cancer.FGFR1 was expressed in all cell types.
|
16996573 |
2007 |
|
Angiogenic Switch
|
0.010 |
Biomarker
|
disease |
BEFREE |
We propose a model for the angiogenic switch based on the autocrine/paracrine FGF-2/FGFR1 activation by PGE(2) and FGF-2 synergistic interaction.
|
19713533 |
2009 |
|
Aortic Valve Insufficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Also, higher androgen/AR signal pathway activity and AR-related cytokines secretion (FGF-2, KGF, IGF-1) were found in PZ-old cells.
|
27178620 |
2016 |
|
Apert syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of FGFR2, however, is restricted to domains of advanced osseous differentiation in both Apert syndrome- and Pfeiffer syndrome-affected cranial skeletogenesis in the presence of fibroblast growth factor (FGF)2, but not in the presence of FGF4 or FGF7.
|
11596961 |
2001 |
|
Aqueous Humor Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
The study showed that the higher levels of IP-10, IL-6, IL-7, IL-8, IFN-γ, PIGF-1, VEGF-A, β-NGF, HGF, EGF and FGF-2 in AH may be associated with RB.
|
28486560 |
2017 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Characterisation of the spatial distribution of the FGFR multigene family in both normal and atherosclerotic arteries is a prerequisite to further define the functional role of FGF-1 and FGF-2 in atherosclerosis.
|
8881516 |
1996 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
18-kDa FGF-2 aggravated the inflammatory reaction of atherosclerosis.
|
29466783 |
2018 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neutrophils induce smooth muscle hyperplasia via neutrophil elastase-induced FGF-2 in a mouse model of asthma with mixed inflammation.
|
30171733 |
2018 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Characterisation of the spatial distribution of the FGFR multigene family in both normal and atherosclerotic arteries is a prerequisite to further define the functional role of FGF-1 and FGF-2 in atherosclerosis.
|
8881516 |
1996 |
|
Atherosclerosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
FGF-2 levels were similar between patients with or without plaque at baseline (79 versus 88 pg/ml), but lower in patients with atheromatosis progression after 2 years (78 versus 98 pg/ml; <i>P</i><0.01).
|
29519952 |
2018 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
18-kDa FGF-2 aggravated the inflammatory reaction of atherosclerosis.
|
29466783 |
2018 |