|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hi-FGF-2 has a significant meaning in AF subjects.
|
28689282 |
2017 |
|
ATRICHIA WITH PAPULAR LESIONS
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
APL expressed high levels of FGF13 and FGFR1 as well as two potent angiogenic factors, HGF and VEGF.
|
15674361 |
2005 |
|
Avascular Necrosis of Femur Head
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
FGF-2 gene overexpression lentivirus transfection BMSCs combined with XACB to construct tissue engineered bone can effectively promote vascular regeneration, and improve the repair effect of avascular necrosis of the femoral head.
|
30025396 |
2018 |
|
Avascular Necrosis of Femur Head
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Effects of transplantation of FGF-2-transfected MSCs and XACB on TNF-α expression with avascular necrosis of the femoral head in rabbits.
|
30377228 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Linear mixed model analyses identified associations linking lower levels of fibroblast growth factor-2 (FGF-2 p = 7.2 × 10<sup>-4</sup> ) and transforming growth factor alpha (TGF-α, p = 6.5 × 10<sup>-5</sup> ) and BCL incidence.
|
29667176 |
2018 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
TCGA data showing a correlation between KDM2B and EZH2 expression and Oncomine data, showing a correlation between KDM2B and tumor progression, strongly support the role of the FGF-2/KDM2B/miR-101/EZH2 pathway in bladder cancer.
|
28515962 |
2017 |
|
Borjeson-Forssman-Lehmann syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The FHF2 gene localisation and tissue-specific expression pattern suggest it to be a candidate gene for familial cases of the BFLS syndrome and other syndromal and non-specific forms of X-linked mental retardation mapping to the region.
|
10071193 |
1999 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In this study we examined by QRT-PCR the mRNA expression of TGF-beta 1, IGF-1, EGF, FGF-2 and YY1 in human brain tumors.
|
19235591 |
2009 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas.
|
9285563 |
1997 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Tubes contained either growth factor-reduced basement membrane extract (BME)-alone (negative control) or BME-containing vascular endothelial growth factor (VEGF)-D (positive control for lymphangiogenesis) or FGF-2/VEGF-A (positive control for angiogenesis) or a high VEGF-D-expressing breast cancer cell line MDA-MD-468LN (468-LN), or VEGF-D-silenced 468LN.
|
23711825 |
2013 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
To test the implicated role of basic fibroblast growth factor (bFGF; FGF-2) in promoting differentiation in breast cancer, we enforced the expression of FGF-2 in T-47D breast cancer cells.
|
11027671 |
2000 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Deletion of Fgf13 in a MMTV-PyMT breast cancer cell line reduces colonization of the lungs in a tail vein injection.
|
31341204 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results clearly argue for a key role of endogenous FGF-2 in transformation and tumorigenesis of the hepatoma cell line used in this study.
|
7585554 |
1995 |
|
Carcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The same analyses also revealed that FGF-2 correlates negatively with the expression, mutation and copy number variations of FGFR-3, all of which are associated with non-invasive bladder carcinomas.
|
28515962 |
2017 |
|
Carcinoma ex pleomorphic adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FGF-2 is overexpressed in myoepithelial cells of carcinoma ex-pleomorphic adenoma in situ structures.
|
20514456 |
2010 |
|
Carcinoma of bladder
|
0.020 |
Biomarker
|
disease |
BEFREE |
They mimicked FGF-1 and FGF-2 for receptor binding, signal transduction, proliferation of endothelial cells and differentiation of the bladder carcinoma cell NBT-II which expresses FGFR-2b but not FGFR-1.
|
15273729 |
2004 |
|
Carcinoma of bladder
|
0.020 |
Biomarker
|
disease |
BEFREE |
TCGA data showing a correlation between KDM2B and EZH2 expression and Oncomine data, showing a correlation between KDM2B and tumor progression, strongly support the role of the FGF-2/KDM2B/miR-101/EZH2 pathway in bladder cancer.
|
28515962 |
2017 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In three cell lines (QG56 from lung cancer, T3M4 and Panc1 from pancreatic cancer), which produced both VEGF and FGF-2 at detectable levels, combined sVEGFR and sFGFR1 produced an enhanced inhibitory effect compared to their individual effects.
|
12136423 |
2002 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
From gene profiling to diagnostic markers: IL-18 and FGF-2 complement CA125 as serum-based markers in epithelial ovarian cancer.
|
16217764 |
2006 |
|
Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results implicate that FGF13 is a critical cardiac Na<sup>+</sup> channel modulator and Fgf13 knockout mice have increased arrhythmia susceptibility in the setting of Na<sup>+</sup> channel blockade.
|
28119060 |
2017 |
|
Central neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells.
|
18469860 |
2008 |
|
Central neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, we have shown for the first time that FGF-2 induces differentiation of neuroblastoma cells via activation of a complex gene expression program enabling modulation of cell cycle, transcription factors, and suppression of the cancer phenotype.
|
19477940 |
2009 |
|
Central neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Induction of Id-1 by FGF-2 involves activity of EGR-1 and sensitizes neuroblastoma cells to cell death.
|
21506108 |
2011 |
|
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining and the RNA-seq (sequencing) data from the IVY Glioblastoma Atlas Project showed FGF13 expression in glioma cells in the invasive edges of tumor specimens.
|
29059154 |
2018 |
|
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GDNF mRNA levels are induced by FGF-2 in rat C6 glioblastoma cells.
|
8883950 |
1996 |