FGFR4, fibroblast growth factor receptor 4, 2264

N. diseases: 220; N. variants: 19
Disease: Liver neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.030 Biomarker group BEFREE The FGFR4/FGF19 signaling axis is overactivated in 20% of liver tumors and currently represents a promising targetable signaling mechanism in this cancer type. 31350344 2019
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.030 Biomarker group BEFREE Accordingly, blockade of FGFR4-mediated signalling by soluble dominant-negative constructs, like solFGFR4, may be a feasible and promising therapeutic approach to antagonize aggressive behaviour of hepatoma/hepatocarcinoma cells. 25031272 2014
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.030 Biomarker group BEFREE The mechanism underlying the FGFR4-mediated hepatoma suppression has not been addressed. 20657013 2010