|
Cardiac Arrhythmia
|
0.210 |
Biomarker
|
phenotype |
RGD |
Decreased FKBP12.6 expression and enhanced endothelin receptor signaling associated with arrhymogenesis in myocardial infarction rats.
|
18570278 |
2008 |
|
Cardiac Arrhythmia
|
0.210 |
Biomarker
|
phenotype |
BEFREE |
Our data suggest that calstabin-2 deficiency is as a critical mediator of triggers that initiate cardiac arrhythmias.
|
16672364 |
2006 |
|
Tachycardia, Ventricular
|
0.210 |
Biomarker
|
disease |
BEFREE |
In calstabin-2-deficient mice, we have now documented diastolic SR Ca2+ leak, monophasic action potential alternans, and bidirectional VT. Calstabin-deficient cardiomyocytes exhibited SR Ca2+ leak-induced aberrant transient inward currents in diastole consistent with delayed after-depolarizations.
|
16672364 |
2006 |
|
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)
|
0.210 |
GeneticVariation
|
disease |
BEFREE |
We have shown that catecholaminergic polymorphic ventricular tachycardia-linked RyR2 mutations significantly decrease the binding affinity for calstabin-2 (FKBP12.6), a subunit that stabilizes the closed state of the channel.
|
16672364 |
2006 |
|
Tachycardia, Ventricular
|
0.210 |
Biomarker
|
disease |
MGD |
|
|
|
|
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)
|
0.210 |
Biomarker
|
disease |
MGD |
|
|
|
|
Cardiomyopathies, Primary
|
0.200 |
Biomarker
|
group |
RGD |
Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats.
|
19000375 |
2008 |
|
Myocardial Diseases, Secondary
|
0.200 |
Biomarker
|
group |
RGD |
Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats.
|
19000375 |
2008 |
|
Cardiomyopathies
|
0.200 |
Biomarker
|
group |
RGD |
Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats.
|
19000375 |
2008 |
|
Heart failure
|
0.200 |
Biomarker
|
disease |
RGD |
Down-regulation of FKBP12.6 and SERCA2a contributes to acute heart failure in septic shock and is related to an up-regulated endothelin signalling pathway.
|
17637193 |
2007 |
|
Congestive heart failure
|
0.200 |
Biomarker
|
disease |
RGD |
Down-regulation of FKBP12.6 and SERCA2a contributes to acute heart failure in septic shock and is related to an up-regulated endothelin signalling pathway.
|
17637193 |
2007 |
|
Ventricular Fibrillation
|
0.200 |
Biomarker
|
disease |
RGD |
Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017.
|
17506935 |
2007 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.020 |
Biomarker
|
disease |
BEFREE |
Differential Proteomic Analysis Reveals Protein Networks and Pathways that May Contribute to Helicobacter pylori FKBP-Type PPIase-Associated Gastric Diseases.
|
29148176 |
2018 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.020 |
Biomarker
|
disease |
BEFREE |
Helicobacter pylori FKBP-type PPIase promotes gastric epithelial cell proliferation and anchorage-independent growth through activation of ERK-mediated mitogenic signaling pathway.
|
25687921 |
2015 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein α -synuclein in cells and interacts with α -synuclein oligomers.
|
31830361 |
2020 |
|
Abscess
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Previously, we identified two PPIase enzymes in <i>Staphylococcus aureus</i> (PpiB and PrsA) that are involved in the regulation of virulence determinants and have shown that PpiB contributes to <i>S. aureus</i> virulence in a murine abscess model of infection.
|
31208155 |
2019 |
|
Stomach Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results provided insight on the protein interaction networks and signaling pathways that may contribute to PPIase-FKBP-associated gastric diseases and may lead to a better understanding of the mechanisms indicating the oncogenic effects of H. pylori PPIase-FKBP.
|
29148176 |
2018 |
|
Arthritis aggravated
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings provide evidence that PPIase CypA promoted macrophages polarization toward pro-inflammatory M1 phenotype via transcriptional activating NF-κB, thus leading to aggravated arthritis.
|
28756520 |
2017 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Evidence of association between FKBP1B and thyroid autoimmune disorders in a large Tunisian family.
|
15497458 |
2004 |
|
Essential Hypertension
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension.
|
14616768 |
2003 |
|
AMYOTROPHIC LATERAL SCLEROSIS 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data suggest that mutant SOD produces a greater need for rotamase and, also, highlights possible new therapeutic strategies in FALS.
|
10077670 |
1999 |