Based on the present study, 'extracellular exosome' processes, 'amoebiasis' pathways, 'ECM‑receptor interaction' pathways and 'focal adhesion' signaling pathways may be important in the formation of metastases from melanoma.
Using quantitative proteomics, we identified and assayed the abundance of 113 ECM proteins, which revealed robust ECM protein signatures unique to fibrosis, primary tumors, or metastases.
We evaluated gene expression profiles using the largest set to date, to our knowledge, of patient-matched primary and metastatic ccRCC tumors and identified up regulation of ECM genes in metastases.