ATF6, activating transcription factor 6, 22926

N. diseases: 179; N. variants: 30
Disease: Fetal Growth Retardation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.020 AlteredExpression phenotype BEFREE The protein levels of activating transcription factor 2 (Atf2) and Atf6, two key factors of the UPR pathway, were upregulated in the livers of IUGR foetuses, and the latter remained upregulated until 12 weeks. 30524373 2018
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.020 AlteredExpression phenotype BEFREE Endoplasmic reticulum (ER) stress has been implicated in both pre-eclampsia (PE) and fetal growth restriction (FGR), and is characterised by activation of three signalling branches: 1) PERK-pEIF2α, 2) ATF6 and 3) splicing of XBP1(U) into XBP1(S). 21907405 2011