ATF6, activating transcription factor 6, 22926

N. diseases: 179; N. variants: 30
Disease: Childhood Liposarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0279984
Disease: Childhood Liposarcoma
Childhood Liposarcoma 		0.010 Biomarker disease BEFREE Time-lapse, confocal microscopic studies show that NFV inhibits the nuclear translocation of full-length SREBP-1-EGFP and ATF6-EGFP fusion proteins. siRNA-mediated knockdown of site-1 protease (S1P) and/or site-2 protease (S2P) leads to inhibition of SREBP-1 intracellular trafficking to the nucleus and reduces liposarcoma cell proliferation. 21355074 2011