SIRT2, sirtuin 2, 22933

N. diseases: 172; N. variants: 4
Disease: Fibrosis, Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.020 Biomarker disease BEFREE Also, the results indicate that Sirt2 inhibition may be a new therapeutic option for controlling HBV infection and preventing HCC.<b>IMPORTANCE</b> Even though Sirt2, a NAD<sup>+</sup>-dependent protein deacetylase, is overexpressed in many HCCs, and overexpressed Sirt2 promotes hepatic fibrosis and associates positively with vascular invasion by primary HCCs through AKT/GSK-3β/β-catenin signaling, the relationship between Sirt2, HBV, HBx, and/or HBV-associated hepatocarcinogenesis is unclear. 30111572 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.020 Biomarker disease BEFREE Inhibition of SIRT2 suppresses hepatic fibrosis. 27125275 2016