Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The increase copy of CNVR_3425.1 forms a new additional truncated FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) sequences comparing the gene promoter and perturbs the transcriptional factors (TFs) binding to the original FENDRR promoter and further downregulates FENDRR, a long intergenic non-coding RNA (lincRNA) that functions to inhibit lung cancer by affecting expressions of an abundant number of genes, including the tumor suppressor FOXF1.
|
29293945 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
As shown in our previous study, FOXF1 is upregulated in 182 CRC tissues, and elevated FOXF1 expression is significantly associated with microvessel density and advanced TNM (T = primary tumour; N = regional lymph nodes; M = distant metastasis) stages.
|
30253191 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Functionally, FOXF1 is required for human GIST cell growth <i>in vitro</i> and murine GIST tumor growth and maintenance <i>in vivo</i> The simultaneous control of the upstream signaling and nuclear response sets up a unique regulatory paradigm and highlights the critical role of FOXF1 in enforcing the GIST cellular context for highly lineage-restricted clinical behavior and treatment response.<b>Significance:</b> We uncover that FOXF1 defines the core-regulatory circuitry in GIST through both direct transcriptional regulation and pioneer factor function.
|
29162563 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The present study demonstrates that expression of FoxF1 and its closely related transcription factor FoxF2 are essential for RMS tumor growth.
|
27425595 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FoxF1 knockdown caused chromosomal instability, nuclear abnormalities, and increased tumor cell death in response to DNA-damaging agents.
|
26625197 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The anti-malignant effects of MSC fusion-induced reprogramming on lung cancer cells were accomplished by complementation of tumorigenic defects, including restoration of p21 function and normal terminal differentiation pathways as well as up-regulation of FOXF1, a putative tumor suppressor.
|
25237908 |
2014 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We also refine a previously reported association with Barrett's esophagus near the putative tumor suppressor gene FOXF1 at 16q24 and extend our findings to now include esophageal adenocarcinoma.
|
24121790 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings for the first time have revealed that the FOXF1 protein is overexpressed as well as mislocalized in cancerous epithelial cells and underexpressed/lost in tumor-associated stromal fibroblasts of colorectal adenocarcinomas, and suggest that FOXF1 is a potential prognostic marker due to its association with the malignancy and metastasis of colorectal cancer.
|
23103611 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously identified FOXF1 as a potential tumor suppressor gene with an essential role in preventing DNA rereplication to maintain genomic stability, which is frequently inactivated in breast cancer through the epigenetic mechanism.
|
21964066 |
2012 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Epigenetic inactivation of the potential tumor suppressor gene FOXF1 in breast cancer.
|
20587515 |
2010 |