Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.020 Biomarker group BEFREE Genetic and functional studies have linked SorCS receptors to psychiatric disorders, Alzheimer's disease and type 2 diabetes, demonstrating critical roles in neuronal functionality and metabolic control. 28827148 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.010 GeneticVariation disease BEFREE Notably, the SORCS3 gene is genome-wide significantly associated with depression and serum protein levels of sortilin are reduced in depressed individuals. 29499509 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.010 GeneticVariation disease BEFREE Notably, the SORCS3 gene is genome-wide significantly associated with depression and serum protein levels of sortilin are reduced in depressed individuals. 29499509 2018
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.010 GeneticVariation disease BEFREE The SORCS3 gene is mutated in brothers with infantile spasms and intellectual disability. 30586538 2018
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.010 GeneticVariation phenotype BEFREE Notably, the SORCS3 gene is genome-wide significantly associated with depression and serum protein levels of sortilin are reduced in depressed individuals. 29499509 2018
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.010 GeneticVariation group BEFREE The SORCS3 gene is mutated in brothers with infantile spasms and intellectual disability. 30586538 2018
CUI: C3887898
Disease: Infantile Spasm
Infantile Spasm 		0.010 GeneticVariation disease BEFREE The SORCS3 gene is mutated in brothers with infantile spasms and intellectual disability. 30586538 2018
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 Biomarker phenotype BEFREE Genetic and functional studies have linked SorCS receptors to psychiatric disorders, Alzheimer's disease and type 2 diabetes, demonstrating critical roles in neuronal functionality and metabolic control. 28827148 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.010 Biomarker disease BEFREE Although additional work is needed to scrutinise the genetic effect of the SORCS3-covering haplotype, this study suggests that SORCS3 may also be important in MS pathogenesis. 26362888 2016