FOXO3, forkhead box O3, 2309

N. diseases: 381; N. variants: 30
Disease: Childhood Acute Lymphoblastic Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.040 GeneticVariation disease BEFREE We genotyped four polymorphisms (rs17069665 A>G, rs4945816 T>C, rs4946936 C>T, and rs9400241 A>C) of FOXO3 in 425 ALL cases and 1339 health controls. 31691337 2020
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.040 Biomarker disease BEFREE Our results therefore demonstrate the therapeutic potential of butein for ALL via FOXO3a/p27kip1 pathway. 26919107 2016
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.040 GeneticVariation disease BEFREE Rs4946936 in FOXO3a was highly associated with an increased risk of childhood ALL in a Chinese population. 25060657 2014
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.040 Biomarker disease BEFREE Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa. 23828551 2013