Our study uncovers a novel molecular mechanism for regulating <i>pd-l1</i> mRNA stability and expression via ATG7/autophagy/FOXO3A/miR-145 axis and reveals the potential for using combination treatment with autophagy inhibitors and PD-1/PD-L1 immune checkpoint blockade to enhance therapeutic efficacy for human BCs.
Overexpression of circ-Foxo3 promoted bladder cancer cell apoptosis in BBN mice and in human bladder cancer cell lines. miR-191-5p suppressed circ-Foxo3 expression and the pro-apoptotic effect of <i>circ-Foxo3</i> in bladder cancer cells via directly targeting the 3'-untranslated region (3'-UTR) of <i>circ-Foxo3</i>.
Knockdown of <i>SIRT1</i> Suppresses Bladder Cancer Cell Proliferation and Migration and Induces Cell Cycle Arrest and Antioxidant Response through FOXO3a-Mediated Pathways.
Studies also implicate FOXA2 in bladder cancer and several other FOX proteins might be involved in development and/or progression of this disease; for example, FOXA1 and FOXO3A have been associated with clinical patient outcomes.