DisGeNET - a database of gene-disease associations

FOXO3, forkhead box O3, 2309

N. diseases: 381; N. variants: 30

Disease: Adult Acute Lymphocytic Leukemia ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C0751606
Disease:	Adult Acute Lymphocytic Leukemia

Adult Acute Lymphocytic Leukemia

0.030

GeneticVariation

disease

BEFREE

We genotyped four polymorphisms (rs17069665 A>G, rs4945816 T>C, rs4946936 C>T, and rs9400241 A>C) of FOXO3 in 425 ALL cases and 1339 health controls.

31691337

2020

CUI:	C0751606
Disease:	Adult Acute Lymphocytic Leukemia

Adult Acute Lymphocytic Leukemia

0.030

Biomarker

disease

BEFREE

Our results therefore demonstrate the therapeutic potential of butein for ALL via FOXO3a/p27kip1 pathway.

26919107

2016

CUI:	C0751606
Disease:	Adult Acute Lymphocytic Leukemia

Adult Acute Lymphocytic Leukemia

0.030

Biomarker

disease

BEFREE

Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa.

23828551

2013