|
Respiratory Syncytial Virus Infections
|
0.310 |
Biomarker
|
group |
CTD_human |
We hypothesize that resveratrol inhibits the TRIF-dependent pathway through upregulation of SARM post-RSV infection.
|
24478430 |
2014 |
|
Respiratory Syncytial Virus Infections
|
0.310 |
AlteredExpression
|
group |
BEFREE |
We hypothesize that resveratrol inhibits the TRIF-dependent pathway through upregulation of SARM post-RSV infection.
|
24478430 |
2014 |
|
Amyotrophic Lateral Sclerosis
|
0.120 |
Biomarker
|
disease |
BEFREE |
Here, we explored whether Sarm1 signalling could be a therapeutic target for ALS by deleting Sarm1 from a mouse model of ALS-FTD, a TDP-43<sup>Q331K</sup>, YFP-H double transgenic mouse.
|
31661035 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.120 |
Biomarker
|
disease |
BEFREE |
Our data suggest the molecular pathways driving axon loss in ALS may be Sarm1-independent or involve genetic pathways that act in a redundant fashion with Sarm1.
|
30010873 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.
|
27455348 |
2016 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Exome-wide association study of plasma lipids in >300,000 individuals.
|
29083408 |
2017 |
|
AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.
|
28931804 |
2017 |
|
AMYOTROPHIC LATERAL SCLEROSIS 1
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.
|
28931804 |
2017 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.
|
28931804 |
2017 |
|
Interleukin 5 Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Connecting genetic risk to disease end points through the human blood plasma proteome.
|
28240269 |
2017 |
|
AMYOTROPHIC LATERAL SCLEROSIS 1, AUTOSOMAL RECESSIVE
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.
|
28931804 |
2017 |
|
Osteoprotegerin test
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
|
25080503 |
2014 |
|
Folate Malabsorption, Hereditary
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Peripheral Neuropathy
|
0.040 |
Biomarker
|
group |
BEFREE |
Notably, SARM1 knockdown or knockout prevents neuron degeneration in response to a range of insults that lead to peripheral neuropathy, traumatic brain injury, and neurodegenerative disease.
|
31761689 |
2020 |
|
Neurodegenerative Disorders
|
0.040 |
Biomarker
|
group |
BEFREE |
Notably, SARM1 knockdown or knockout prevents neuron degeneration in response to a range of insults that lead to peripheral neuropathy, traumatic brain injury, and neurodegenerative disease.
|
31761689 |
2020 |
|
Peripheral Nervous System Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
Notably, SARM1 knockdown or knockout prevents neuron degeneration in response to a range of insults that lead to peripheral neuropathy, traumatic brain injury, and neurodegenerative disease.
|
31761689 |
2020 |
|
Peripheral Neuropathy
|
0.040 |
Biomarker
|
group |
BEFREE |
Here, we will present evidence that inhibiting the SARM1 pathway can prevent the development of peripheral neuropathy, describe the emerging mechanistic understanding of the axon degeneration program, and discuss how these mechanistic insights may be translated to the clinic for the prevention and treatment of peripheral neuropathy and other neurodegenerative disorders.
|
31008845 |
2019 |
|
Neuropathy
|
0.040 |
GeneticVariation
|
group |
BEFREE |
We showed previously that genetic deletion of SARM1 blocks vincristine-induced neuropathy and demonstrate here that it also prevents axon destruction following administration of bortezomib in vitro and in vivo.
|
31484833 |
2019 |
|
Neuropathy
|
0.040 |
Biomarker
|
group |
BEFREE |
We, therefore, developed SARM1 dominant-negatives that potently block AxD in cellular models of axotomy and neuropathy.
|
30642945 |
2019 |
|
Neuropathy
|
0.040 |
Biomarker
|
group |
BEFREE |
SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD<sup>+</sup>) during Wallerian degeneration associated with neuropathies.
|
31439792 |
2019 |