Disease: Sclerosis of the skin ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0263009
Disease: Sclerosis of the skin
Sclerosis of the skin 		0.020 Biomarker disease BEFREE Constitutive activation of the c-Abl/PKC-δ/Fli1 pathway at least partially contributes to the establishment of the profibrotic phenotype in LSc dermal fibroblasts, which provides a novel molecular basis to explain the efficacy of imatinib against skin sclerosis in a certain subset of LSc. 22591006 2012
CUI: C0263009
Disease: Sclerosis of the skin
Sclerosis of the skin 		0.020 Biomarker disease BEFREE In contrast to healthy skin, Fli1 protein is consistently absent from fibroblasts and significantly reduced in endothelial cells in clinically involved scleroderma skin, which correlates with enhanced collagen synthesis in systemic sclerosis skin. 12875977 2003