KDM6B, lysine demethylase 6B, 23135

N. diseases: 173; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.120 Biomarker phenotype BEFREE Selective Kdm6b knockdown in the ventral hippocampus led to behavioral hyperactivity/hyperresponsiveness. 29605177 2018
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.120 AlteredExpression phenotype BEFREE Moreover, overexpressing JMJD3 through the transfection of pcDNA3.1-JMJD3 into healthy donor CD4+ T cells increased JMJD3 enrichment and decreased H3K27me3 enrichment within the ITGAL (CD11a) promoter and up-regulated CD11a expression, leading to T and B cell hyperactivity. 28430662 2017
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.120 Biomarker phenotype HPO