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Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, the identification of DNA lesion 5-chlorocytosine (5-CIC) created by hypochlorous acid (HOCl) secreted to nullify or kill infectious agents and toll-like receptor 4 (TLR4)-mediated chronic inflammation in the human gut, has become the latest evidence linking inflammation directly to cancer.
|
30906626 |
2019 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Arkaitz Carracedo is a principal investigator at the Association for Cooperative Research in Biosciences (CIC bioGUNE) in Spain; his laboratory focuses on signaling and metabolic alterations in cancer.
|
31615839 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, deletion of CIC caused a significant increase in tumor growth <i>in vivo</i> These results show that the RAS-MAPK pathway is involved in tumor progression and establish CIC as a powerful tumor suppressor that functions downstream of this pathway in neuroblastoma.<b>Significance:</b> This work identifies CIC as a powerful tumor suppressor affecting the RAS-MAPK pathway in neuroblastoma and reinforces the importance of mutation-driven activation of this pathway in cancer.<i>Cancer Res; 78(21); 6297-307.©2018 AACR</i>.
|
30115695 |
2018 |
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Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CIC-NUTM1 fusion: A case which expands the spectrum of NUT-rearranged epithelioid malignancies.
|
29700887 |
2018 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, our results show that CIC is a transcriptional repressor of genes regulated by MAPK signaling, and that ablation of CIC function leads to increased histone acetylation levels and transcription at these genes, ultimately fueling mitogen-independent tumor growth.<b>Significance:</b> Inactivation of CIC inhibits its direct repression of MAPK pathway genes, leading to their increased expression and mitogen-independent growth.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/15/4114/F1.large.jpg <i>Cancer Res; 78(15); 4114-25.©2018 AACR</i>.
|
29844126 |
2018 |
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Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Downregulation of CIC abrogates the effect of MAPK inhibitors, suggesting its potential role as an important modifier of molecular target therapies for cancer.
|
28985030 |
2017 |
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Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
OR7C1 is a novel marker for colon CICs and can be a target of potent CIC-targeting immunotherapy.Clin Cancer Res; 22(13); 3298-309.©2016 AACR.
|
26861454 |
2016 |
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Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results identify CIC as a novel target of mutp53 and imply that the employment of CIC inhibitors may improve survival rates and reduce chemo-resistance in tumors harboring these types of mutations, which are among the most intractable forms of cancers.
|
24681808 |
2014 |
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Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together with recent reports showing that CIC gene signatures influence patient survival, these studies predict that targeting self-renewal, the key 'stemness' property unique to CICs, may represent a new paradigm in cancer therapy.
|
24292392 |
2014 |
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Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings reveal that CIC maintains mitochondrial homeostasis in metabolically active, high proliferating tissues and imply that this protein is a therapeutic target in cancer and likely, in other human diseases.
|
23100451 |
2012 |
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Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cancer stem cells/initiating cells (CSC/CIC), are thought to exist as a small population in malignant tissues.
|
21079774 |
2010 |