|
Constitutional obesity
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These results confirm a putative role of TBC1D1 R125W variant in familial obesity predisposition.
|
18325908 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In humans, variants in TBC1D1 and TBC1D4 are linked to obesity and insulin resistance and type 2 diabetes.
|
31627187 |
2020 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
Two related RabGAPs, TBC1D1 and TBC1D4 (=AS160) have been described to be associated with obesity-related traits and type 2 diabetes in both mice and humans.
|
29784647 |
2018 |
|
Tuberculosis, Multidrug-Resistant
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this cohort study (involving record review) of all diagnosed MDR-TB between January 2015 and June 2016 in project townships, CBMDR-TBC status was categorized as "receiving support" if date of project initiation in patient's township was before the date of diagnosis and "not receiving support", if otherwise.
|
29596434 |
2018 |
|
Tuberculosis, Multidrug-Resistant
|
0.020 |
Biomarker
|
disease |
BEFREE |
Implementation of CBMDR-TBC coincided with implementation of decentralized MDR-TB centers at district level.
|
29261669 |
2017 |
|
Tuberculosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Compared to many other conventional NAAT assays, the hyplex TBC PCR test is in a low price segment which makes it an attractive option for developing and emerging countries with high TB burdens.
|
20356361 |
2010 |
|
Obesity, Morbid
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Stone et al. previously reported an association between the TBC1D1 gene variant rs35859249" genes_norm="23216">R125W (rs35859249) and severe obesity in women from US pedigrees.
|
18325908 |
2008 |
|
Obesity, Morbid
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here, we present evidence that genetic variation in TBC1D1 confers risk for severe obesity in females.
|
16893906 |
2006 |
|
Tuberculosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Diagnosis of tuberculosis (TB), especially cutaneous TBC, by conventional microbiologic methods is still a very laborious process and the results are usually inconclusive.
|
8655234 |
1996 |
|
Diabetic Cardiomyopathies
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Since mutations within TBC1D1 (R125W) display stronger associations with clinical parameters in women, we further examined possible sex differences in the predisposition to diabetic cardiomyopathy.
|
31845331 |
2020 |
|
Cardiomyopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
When challenged with an 8-week high-fat diet, TBC1D1 KO rats displayed a 4-fold increase in fibrosis compared to WT animals, and this was associated with diastolic dysfunction, suggesting a predisposition to diet-induced cardiomyopathy.
|
31845331 |
2020 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Endurance running exercise is an effective alternative to estradiol replacement for restoring hyperglycemia through TBC1D1/GLUT4 pathway in skeletal muscle of ovariectomized rats.
|
31782092 |
2019 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A Phase I HIV-1 prophylactic vaccine trial sponsored by the International AIDS Vaccine Initiative (IAVI) was conducted in India in 2009.The trial tested a HIV-1 subtype C vaccine in a prime-boost regimen, comprising of a DNA prime (ADVAX) and Modified Vaccine Ankara (MVA) (TBC-M4) boost.
|
30921340 |
2019 |
|
Diabetes
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
TBC update: personalized epigenetic management of diabetes.
|
29749858 |
2017 |
|
Diabetes Mellitus
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
TBC update: personalized epigenetic management of diabetes.
|
29749858 |
2017 |
|
Congenital anomaly of the kidney
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Whole-exome sequencing identifies mutations of TBC1D1 encoding a Rab-GTPase-activating protein in patients with congenital anomalies of the kidneys and urinary tract (CAKUT).
|
26572137 |
2016 |
|
Renal dysplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Significantly reduced Glut4 levels were detected in kidneys of Tbc1d1 (-/-) mice and the dysplastic kidney of a TBC1D1 mutation carrier versus controls.
|
26572137 |
2016 |
|
Schizophrenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We analyzed rs9852 and rs35859249 in TBC1D1 in 195 schizophrenia subjects treated mostly with clozapine or olanzapine for up to 14 weeks.
|
23364847 |
2013 |
|
Bone Cysts, Aneurysmal
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this review, we discuss the most up-to-date findings on the molecular functions of TRE17, the role of its USP and TBC domains, and potential models for how it contributes to transformation and ABC pathogenesis.
|
22202063 |
2012 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
However, the mechanisms by which TRE17 overexpression contributes to tumor pathogenesis, and the role of its USP and TBC domains, are unknown.
|
20418905 |
2010 |
|
Stage 4S neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma.
|
9618176 |
1998 |