|
Leukocytosis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
This report describes a 43-year-old patient with FLT3-internal tandem duplication (FLT3-ITD) positive acute myeloid leukemia who initially presented with leukocytosis and concern for acute leukemia.
|
29558838 |
2019 |
|
Leukocytosis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Analysis of a validation cohort of 80 elderly patients treated with myelosuppressive chemotherapy confirmed that relative BAX localization correlates with probability of disease progression, FLT3-ITD status, and leukocytosis.
|
28420723 |
2017 |
|
Leukocytosis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
FLT3-ITD has been strongly associated with a bad prognosis, leukocytosis, high blast counts, increased risk of relapse and shorter overall survival.
|
28470536 |
2017 |
|
Leukocytosis
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Analysis of hematopathology and alteration of JAK1/STAT3/STAT5 signaling axis in experimental myelodysplastic syndrome.
|
27725143 |
2016 |
|
Leukocytosis
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.
|
27099147 |
2016 |
|
Leukocytosis
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
FLT3/ITD mutation was found to be associated with the age, leukocytosis and aberrant expression of CD7, although no influence of FLT3/ITD mutation was seen on the clinical outcome of AML patients with normal cytogenetics.
|
20354824 |
2011 |
|
Leukocytosis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Multivariate analysis showed the effects of leukocytosis (p = 0.0013), antecedent Myelodysplastic syndrome (MDS) (p = 0.011), FLT3 abnormalities (p = 0.032), CCI (p = 0.0037) and Dombret et al. score (p = 0.045) as independent prognostic parameters for survival.
|
19274612 |
2009 |
|
Leukocytosis
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Several large-scale studies have confirmed that FLT3/ITD is strongly associated with leukocytosis and a poor prognosis.
|
16146837 |
2005 |
|
Leukocytosis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
FLT3/ITD was associated to leukocytosis and lower complete remission (CR) rate, and was more prevalent in patients with normal karyotype.
|
15996732 |
2005 |
|
Leukocytosis
|
0.400 |
GeneticVariation
|
phenotype |
LHGDN |
FLT3 abnormalities were associated with leukocytosis (ITD P < 0.01; ATKD P = 0.069), and the monocytic FAB subtypes M4 and M5 [ITD (P < 0.05), ATKD (P = 0.05)], and ITD and ATKD were significantly (P < 0.05) more common in cases with a normal karyotype.
|
15059064 |
2004 |
|
Leukocytosis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
FLT3 abnormalities were associated with leukocytosis (ITD P < 0.01; ATKD P = 0.069), and the monocytic FAB subtypes M4 and M5 [ITD (P < 0.05), ATKD (P = 0.05)], and ITD and ATKD were significantly (P < 0.05) more common in cases with a normal karyotype.
|
15059064 |
2004 |
|
Leukocytosis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
FLT3-ITD is associated with leukocytosis and a poor prognosis, especially in patients with normal karyotype.
|
12750701 |
2003 |
|
Leukocytosis
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
An internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 (FLT3/ITD) has been found in 20% of patients with acute myeloid leukemia (AML) and is correlated with leukocytosis and a poor prognosis.
|
12842996 |
2003 |
|
Leukocytosis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
FLT3-ITDs induced an oligoclonal myeloproliferative disorder in mice, characterized by splenomegaly and leukocytosis.
|
11756186 |
2002 |
|
Leukocytosis
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
An FLT3/ITD mutation was present in 27% of the patients and was associated with leukocytosis and a high percentage of bone marrow blast cells (P <.001 for both).
|
11535508 |
2001 |
|
Leukocytosis
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
An internal tandem duplication (ITD) of the juxtamembrane (JM) domain-coding sequence of the FLT3 gene (FLT3/ITD) is found in 20% of patients with acute myeloid leukemia (AML) and is strongly associated with leukocytosis and a poor prognosis.
|
11290608 |
2001 |
|
Leukocytosis
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Univariate analysis showed that unfavorable prognostic factors for overall survival were age 60 years or older (P =.0002), cytogenetic data (P =.002), FAB types other than M2 (P =.002), leukocytosis over 100 +/- 10(9)/L (P =.003), and the FLT3 gene mutation (P =.004).
|
10216104 |
1999 |
|
Leukocytosis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho).
|
9305596 |
1997 |