|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The mutational spectrum of FLT3 gene in acute lymphoblastic leukemia is different from acute myeloid leukemia.
|
31285539 |
2020 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
In leukemia, FLT3 was found to be significantly upregulated in acute myeloid leukemia and acute lymphoblastic leukemia, and a high expression of FLT3 contributed to reduced survival rates.
|
29257272 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Fms-like tyrosine kinase 3 (FLT3) is highly expressed in mixed-lineage leukemia (MLL) gene-rearranged acute lymphoblastic leukemia (MLL+ALL) with a dismal prognosis.
|
28917156 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
<b>Purpose:</b> The FLT3 cell-surface receptor tyrosine kinase (CD135) is expressed in a majority of both acute lymphoid leukemia (ALL) and myeloid leukemia (AML).
|
28108543 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.
|
27181063 |
2016 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Our previous data demonstrated specific up-regulation of miR-155 in FLT3-ITD+ AML. miR-155 is known to be directly implicated in normal hematopoiesis and in some pathologies such as myeloid hyperplasia and acute lymphoblastic leukemia.
|
26055960 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The incorporation of ABL kinase inhibitors into acute lymphoblastic leukemia management should serve as a model for incorporation of FLT3-targeted agents into clinical care.
|
24468836 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Impact of mutations in FLT3, PTPN11 and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil.
|
24067137 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The present study employed single cell mutation analysis to evaluate the FLT3-ITD status in newly diagnosed acute myeloid leukemia (n = 5) and acute lymphocytic leukemia (n = 3) patients.
|
24495871 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Two of 25 ALL patients (8%) showed a mutated band of FLT3-ITD mutation representing 12.5% of pediatric patients, and all the other ALL cases showed the absence of this mutation.
|
24390456 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
High FLT3 expression and IL10 (G1082A) polymorphism in poor overall survival in calla acute lymphoblastic leukemia.
|
23086275 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
To further explore the efficacy of targeted therapies, we demonstrate that T-ALL cell lines transfected with FLT3 expression constructs were particularly sensitive to tyrosine kinase inhibitors.
|
23359050 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia.
|
22705992 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
FLT3 is expressed at high levels in 70-100% of cases of AML and in virtually all cases of B-lineage acute lymphoblastic leukemia.
|
22049994 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
FLT3 mutations in canine acute lymphocytic leukemia.
|
21272320 |
2011 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.
|
17910045 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
FLT3/ITDs in the juxtamembrane domain were found in 25% of patients with acute myeloid leukemia and 7% of patients with acute lymphoid leukemia.
|
18925699 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
LHGDN |
We will highlight the role of FLT3 in hematopoiesis, and how when activated, it may play a role in the development of acute myeloid or acute lymphoblastic leukemia.
|
17584026 |
2007 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
LHGDN |
Prognostic significance of high-level FLT3 expression in MLL-rearranged infant acute lymphoblastic leukemia.
|
17881645 |
2007 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Fms-like tyrosine kinase 3 (FLT3) is highly expressed in acute lymphoblastic leukemia with the mixed-lineage leukemia (MLL) gene rearrangement refractory to chemotherapy.
|
17942916 |
2007 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
FLT3 is widely expressed in AML and some cases of acute lymphocytic leukemia.
|
15604885 |
2005 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
LHGDN |
FLT3 is widely expressed in AML and some cases of acute lymphocytic leukemia.
|
15604885 |
2005 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Although FLT3 mutations are essentially found in myeloid-lineage leukemia cells, a high level of FLT3 expression was recently observed in MLL gene-rearranged acute lymphoblastic leukemia without FLT3 mutations.
|
14604973 |
2004 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias.
|
15044257 |
2004 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
FLT3 mutations in childhood acute lymphoblastic leukemia.
|
14670924 |
2004 |