Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|
17554260 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits.
|
17632545 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits.
|
17632545 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits.
|
17632545 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
CTD_human |
These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits.
|
17632545 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
According to a case-control study and logistic regression adjusting for sex and age, we observed that these SNPs in ERBB3 and CLEC16A were both significantly associated with T1D, with the risk alleles being consistent with those in white populations [adjusting odds ratio by multiplicative model: 1.37 (1.13-1.67), P = 0.001; and 1.28 (1.02-1.60), P = 0.030, respectively].
|
18940880 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway.
|
18946483 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
CTD_human |
Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway.
|
18946483 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The intron polymorphism rs725613 in the KIAA0350 gene is associated with susceptibility to T1D, and this association is not race specific.
|
19178520 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Associations of CLEC16A polymorphisms with T1D and MS were successfully replicated in a Spanish population.
|
19221398 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Independent genome-wide association studies highlighted the function of CLEC16A/KIAA0350 polymorphisms modifying the risk to either multiple sclerosis (rs6498169) or type 1 diabetes (rs2903692).
|
19337309 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition to the support for previously identified loci (PTPN22/1p13; ERBB3/12q13; SH2B3/12q24; CLEC16A/16p13; UBASH3A/21q22), evidence supporting two new and distinct chromosome locations associated with T1D was observed: FHOD3/18q12 (rs2644261, P=5.9 x 10(-4)) and Xp22 (rs5979785, P=6.8 x 10(-3); http://www.T1DBase.org).
|
19956107 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CLEC16A, a putative immunoreceptor, was recently established as a susceptibility locus for type I diabetes and multiple sclerosis.
|
20220768 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genomewide association studies have implicated the CLEC16A gene in several autoimmune diseases, including multiple sclerosis (MS) and type 1 diabetes.
|
21179112 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
PTPN22 (1p13.2), STAT4 (2q32.2), CTLA4 (2q33.2), HLA (6p21), IL2RA (10p15.1), INS (11p15.5), ERBB3 (12q13.2), SH2B3 (12q24.12), and CLEC16A (16p13.13) were convincingly associated with autoimmune diabetes in adults (P ≤ 0.002), with consistent directions of effect as reported for pediatric type 1 diabetes.
|
21873553 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
In reciprocal experiments, a 20 kb fragment of intron 19 of CLEC16A, containing SNPs associated with T1D and MS, as well as with DEXI expression, interacted with the promotor region of DEXI but not with candidate DNA fragments containing other potential causal genes in the region, including CLEC16A.
|
21989056 |
2012 |